Neutrophil to Lymphocyte Ratio as Predictor of Surgical Mortality and Survival in Complex Surgery of the Upper Gastrointestinal Tract
Document title: Neutrophil to Lymphocyte Ratio as Predictor of Surgical Mortality and Survival in Complex Surgery of the Upper Gastrointestinal Tract
Journal: Revista de investigación clínica
Database: PERIÓDICA
System number: 000390745
ISSN: 0034-8376
Authors: 1
1
1
Institutions: 1Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Departamento de Cirugía, México, Distrito Federal. México
Year:
Season: Mar-Abr
Volumen: 67
Number: 2
Pages: 117-121
Country: México
Language: Inglés
Document type: Estadística o encuesta
Approach: Analítico
English abstract Neutrophil-lymphocyte ratio (NLR) has been proposed as a marker of inflammatory response and as a prognostic tool in surgical procedures. Objective: To evaluate the role of high preoperative NLR (> 4.5) as predictor of morbidity and mortality in patients with upper gastrointestinal tract resection, and survival in cancer patients. Methods: Retrospective study of patients undergoing upper gastrointestinal tract surgery from 2007 to 2012. Variables associated with morbidity, mortality, and survival were analyzed. Univariate and multivariate analyses were performed. Significance was considered at p < 0.05. Results: 548 patients were included. The most common surgical procedures were Whipple (44.3%) and gastrectomy (30.7%). Surgical morbidity was 40.5% and mortality 6.4%. Factors associated with significant surgical complications were: low body mass index, AJCC stage ≥ III and ASA ≥ III. Factors associated with mortality were older patient age, high NLR, AJCC stage ≥ III, ASA ≥ III, blood transfusion and Charlson > 4. On multivariate analysis, only high NLR and Charlson > 4 remained significant. High NLR was significantly associated with reduced survival in patients with malignant neoplasms (three-year survival 76.1 vs. 65.7%; p = 0.04). Conclusion: High preoperative NLR appears to be a biomarker to predict surgical mortality and survival in patients undergoing complex surgery of the upper gastrointestinal tract
Disciplines: Medicina
Keyword: Diagnóstico,
Gastroenterología,
Oncología,
Neoplasias,
Sistema digestivo,
Morbilidad,
Mortalidad,
Sobrevivencia,
Pronóstico,
Respuesta inflamatoria,
Marcadores
Keyword: Medicine,
Diagnosis,
Gastroenterology,
Oncology,
Neoplasms,
Digestive tract,
Morbidity,
Mortality,
Survival,
Prognosis,
Inflammatory response,
Markers
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