Neutrophil to Lymphocyte Ratio as Predictor of Surgical Mortality and Survival in Complex Surgery of the Upper Gastrointestinal Tract
Título del documento: Neutrophil to Lymphocyte Ratio as Predictor of Surgical Mortality and Survival in Complex Surgery of the Upper Gastrointestinal Tract
Revista: Revista de investigación clínica
Base de datos: PERIÓDICA
Número de sistema: 000390745
ISSN: 0034-8376
Autors: 1
1
1
Institucions: 1Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Departamento de Cirugía, México, Distrito Federal. México
Any:
Període: Mar-Abr
Volum: 67
Número: 2
Paginació: 117-121
País: México
Idioma: Inglés
Tipo de documento: Estadística o encuesta
Enfoque: Analítico
Resumen en inglés Neutrophil-lymphocyte ratio (NLR) has been proposed as a marker of inflammatory response and as a prognostic tool in surgical procedures. Objective: To evaluate the role of high preoperative NLR (> 4.5) as predictor of morbidity and mortality in patients with upper gastrointestinal tract resection, and survival in cancer patients. Methods: Retrospective study of patients undergoing upper gastrointestinal tract surgery from 2007 to 2012. Variables associated with morbidity, mortality, and survival were analyzed. Univariate and multivariate analyses were performed. Significance was considered at p < 0.05. Results: 548 patients were included. The most common surgical procedures were Whipple (44.3%) and gastrectomy (30.7%). Surgical morbidity was 40.5% and mortality 6.4%. Factors associated with significant surgical complications were: low body mass index, AJCC stage ≥ III and ASA ≥ III. Factors associated with mortality were older patient age, high NLR, AJCC stage ≥ III, ASA ≥ III, blood transfusion and Charlson > 4. On multivariate analysis, only high NLR and Charlson > 4 remained significant. High NLR was significantly associated with reduced survival in patients with malignant neoplasms (three-year survival 76.1 vs. 65.7%; p = 0.04). Conclusion: High preoperative NLR appears to be a biomarker to predict surgical mortality and survival in patients undergoing complex surgery of the upper gastrointestinal tract
Disciplines Medicina
Paraules clau: Diagnóstico,
Gastroenterología,
Oncología,
Neoplasias,
Sistema digestivo,
Morbilidad,
Mortalidad,
Sobrevivencia,
Pronóstico,
Respuesta inflamatoria,
Marcadores
Keyword: Medicine,
Diagnosis,
Gastroenterology,
Oncology,
Neoplasms,
Digestive tract,
Morbidity,
Mortality,
Survival,
Prognosis,
Inflammatory response,
Markers
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