| Journal: | Journal of the Mexican Chemical Society |
| Database: | PERIÓDICA |
| System number: | 000405323 |
| ISSN: | 1665-9686 |
| Authors: | Ma, Wei1 Ding, Yunyun1 Liu, Feng1 Zhang, Yue1 Li, Ning1 |
| Institutions: | 1Anhui Medical University, School of Pharmacy, Hefei, Anhui. China |
| Year: | 2016 |
| Season: | Abr-Jun |
| Volumen: | 60 |
| Number: | 2 |
| Pages: | 83-88 |
| Country: | México |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, analítico |
| Spanish abstract | Se elucidaron las estructuras de 1 y 2 mediante análisis espectrocópicos de RMN de 1H y 13C, COSY, HSQC, HMBC, y HRMS, mientras que las estructuras de los compuestos conocidos se dedujeron por comparación de sus datos espectrales con los de la literatura. Los nuevos compuestos 1 y 2 fueron evaluados contra cinco líneas celulares cancerígenas humanas (SHSY-5Y, SMMC-7721, HepG-2, Hela, and MCF-7) mediante el ensayo CCK-8. Solamente el compuesto 1 mostró una débil actividad citotóxica contra la línea SMMC-7721 con un valor de IC50 de 57.5 μM. También se evaluó el efecto inhibitorio de los compuestos 1 y 2 en la producción de óxido nítrico (NO) en macrófagos RAW264.7 inducidos por lipopolisacáridos. Ambos compuestos mostraron buena actividad inhibitoria con valores de IC50 de 8.59 y 13.73 μM, respectivamente |
| English abstract | A new sesquilignan effususin E (1) and a new long chain fatty enamide effususin F (2), together with eight known compounds were isolated from the medullae of Juncus effusus. The structures of 1 and 2 were elucidated by detailed spectroscopic analysis including 1H and 13C NMR, COSY, HSQC, HMBC, and HRMS, while the structures of the known compounds were deduced from comparison of their spectral data with those in the literature. The new compounds 1 and 2 were evaluated against five human cancer cell lines (SHSY-5Y, SMMC-7721, HepG-2, Hela, and MCF-7) by CCK-8 assay, but only 1 exhibited weak cytotoxic activity against SMMC-7721 with IC50 value of 57.5 μm. Inhibitory effects of 1 and 2 on nitric oxide (NO) production in lipopolysaccharide-induced RAW264.7 macrophages were also evaluated, and they were found to exhibit good inhibitory activities with IC50 values of 8.59 and 13.73 μm, respectively |
| Disciplines: | Biología, Química |
| Keyword: | Angiospermas, Fitoquímica, Química farmacéutica, Juncus effusus, Plantas medicinales, China, Actividad citotóxica, Actividad antiinflamatoria |
| Keyword: | Biology, Chemistry, Angiosperms, Medicinal chemistry, Phytochemistry, Juncus effusus, Medicinal plants, China, Cytotoxic activity, Antiinflammatory activity |
| Full text: | Texto completo (Ver HTML) |
