Polymorphisms FTO rs9939609, PPARG rs1801282 and ADIPOQ rs4632532 and rs182052 but not lifestyle are associated with obesity related-traits in Mexican children
Document title: Polymorphisms FTO rs9939609, PPARG rs1801282 and ADIPOQ rs4632532 and rs182052 but not lifestyle are associated with obesity related-traits in Mexican children
Journal: Genetics and molecular biology
Database: PERIÓDICA
System number: 000401304
ISSN: 1415-4757
Authors: 1
2
3
2
4
4
1
Institutions: 1Universidad Juárez del Estado de Durango, Facultad de Medicina, Durango. México
2Universidad Juárez del Estado de Durango, Facultad de Ciencias Químicas, Durango. México
3Universidad Autónoma Metropolitana, Departamento de Economía, Iztapalapa, Ciudad de México. México
4Universidad Autónoma del Estado de Morelos, Facultad de Ciencias, Cuernavaca, Morelos. México
Year:
Season: Dic
Volumen: 39
Number: 4
Pages: 547-553
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Experimental, aplicado
English abstract Concerning the genetic factors of obesity, no consistent association between populations has been reported, which may be due to the frequency of polymorphisms, the lifestyle of studied populations and its interaction with other factors. We studied a possible association of polymorphisms FTO rs9939609, PPARG rs1801282, and ADIPOQ rs4632532 and rs182052 with obesity phenotypes in 215 Mexican children. Glucose, triglycerides, cholesterol, HDL and LDL were measured. In addition, weight, height, waist circumference and triceps skin thickness were recorded. High-energy diets and sedentary behavior were evaluated with a validated questionnaire. In contrast with other reports, only FTO rs9939609 was associated with obesity related-traits, including BMI (p = 0.03), waist circumference (p = 0.02), triceps skinfold (p = 0.03) and waist/height ratio (p = 0.01), and also with cholesterol levels (p = 0.02) and LDL (p = 0.009). Lower levels of triglycerides (p=0.04) were related with presence of PPARG rs1801282, while ADIPOQ rs4632532 showed an effect on HDL (p = 0.03) levels. On the other hand, diet, physical activity and screen time were not related with obesity. In summary, only FTO rs9939609 was associated with obesity related-traits, while PPARG2 rs1801282 and ADIPOQ rs4632532 were involved in lipid metabolism
Disciplines: Medicina
Keyword: Metabolismo y nutrición,
Pediatría,
Genética,
Niños,
Obesidad,
Perfil lipídico,
Actividad física,
Polimorfismo genético
Keyword: Medicine,
Metabolism and nutrition,
Pediatrics,
Genetics,
Children,
Obesity,
Lipid profile,
Physical activity,
Genetic polymorphism
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