| Journal: | Anais brasileiros de dermatologia |
| Database: | PERIÓDICA |
| System number: | 000408848 |
| ISSN: | 0365-0596 |
| Authors: | Viana, Ana Carolina Leite1 Goulart, Eugenio Marcos Andrade2 Gontijo, Bernardo1 Bittencourt, Flavia Vasques1 |
| Institutions: | 1Universidade Federal de Minas Gerais, Hospital das Clinicas, Belo Horizonte, Minas Gerais. Brasil 2Universidade Federal de Minas Gerais, Faculdade de Medicina, Belo Horizonte, Minas Gerais. Brasil |
| Year: | 2017 |
| Season: | Mar-Abr |
| Volumen: | 92 |
| Number: | 2 |
| Pages: | 201-206 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | Large congenital melanocytic nevus (LCMN) is considered a risk factor for melanoma, although the magnitude of this risk is controversial. Objective: To evaluate the risk of melanoma development in patients with LCMN seen at a dermatology referral center in Brazil during a twelve-year period. To the best of our knowledge, there are no published similar studies on large congenital melanocytic nevus in South America. Methods: Our prospective cohort included only patients with congenital nevi ≥20cm. The cumulative risk of developing melanoma and the standardized morbidity ratio were calculated for patients followed up prospectively for at least 1 month. Results: Sixty-three patients were enrolled in this study. One patient who developed melanoma prior to enrollment was excluded, and five were eliminated because of insufficient follow-up time. Mean follow-up for the remaining 57 patients was 5.5 years (median 5.2 years). Median age of entry into the study was 2.6 years. Most patients (75.4%) underwent only clinical observation. Melanomas occurred in 2 (3.5%) patients. Five-year cumulative risk for melanoma was 4.8% (95% CI: 1.9-11.5%). Standardized morbidity ratio was 1584 (95% CI: 266-5232, p<0.001). Study limitations: The small sample size reduces the accuracy of risk estimates. Conclusions: This study analyzed prospectively for the first time data from South America demonstrating that patients with LCMN have a higher risk of developing melanoma than the general population (p<0.001) |
| Disciplines: | Medicina |
| Keyword: | Dermatología, Oncología, Anomalías congénitas, Nevo melanocítico, Factores de riesgo, Melanoma |
| Keyword: | Medicine, Dermatology, Oncology, Congenital anomalies, Melanocytic nevus, Risk factors, Melanoma |
| Full text: | Texto completo (Ver HTML) |
