Effect of N-acetyl-L-cysteine on lymphocyte apoptosis, lymphocyte viability, TNF-alpha and IL-8 in HIV-infected patients undergoing anti-retroviral treatment



Título del documento: Effect of N-acetyl-L-cysteine on lymphocyte apoptosis, lymphocyte viability, TNF-alpha and IL-8 in HIV-infected patients undergoing anti-retroviral treatment
Revista: The brazilian journal of infectious diseases
Base de datos: PERIÓDICA
Número de sistema: 000290843
ISSN: 1413-8670
Autores: 1

2


3
4
5
6
Instituciones: 1Universidade Federal de Santa Catarina, Centro de Ciencias da Saude, Florianopolis, Santa Catarina. Brasil
2Hospital Nereu Ramos, Florianopolis, Santa Catarina. Brasil
3Secretaria da Saude, Florianopolis, Santa Catarina. Brasil
4Hospital da Universidade Federal de Santa Catarina, Florianopolis, Santa Catarina. Brasil
5Hemocentro de Santa Catarina, Florianopolis, Santa Catarina. Brasil
6Universidade de Sao Paulo, Sao Paulo. Brasil
Año:
Periodo: Oct
Volumen: 8
Número: 5
Paginación: 363-371
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Caso clínico
Resumen en inglés N-acetyl-L-cysteine (NAC) has been proposed as an additional therapeutic agent for AIDS patients because it reduces human immunodeficiency virus type 1 (HIV-1) replication in stimulated CD4+ lymphocytes, and it ameliorates immunological reactivity. In a randomized, 180-day, double-blind, placebo-controlled trial performed with HIV-infected patients classified as A2 and A3 according to the criteria of the Center for Disease Control and Prevention, we investigated the effects of oral administration of NAC on HIV-infected patients undergoing their first anti-retroviral therapy; viral load, CD4+ lymphocyte, lymphocyte viability and apoptosis, and TNF-alpha and IL-8 levels were determined. Sixteen patients who received anti-retroviral therapy plus a placebo formed the control group and the study group consisted of 14 patients who received anti-retroviral therapy and NAC supplementation. A significant decrease was seen in viral load, TNF-alpha and IL-8 levels, and lymphocyte apoptosis, and a significant increase was found in levels of CD4+ lymphocytes and lymphocyte viability in both groups after anti-retroviral treatment, but no measurable benefits of anti-retroviral therapy plus NAC oral supplementation (600 mg/day) were found in relation to anti-retroviral therapy alone, and the baseline levels of cysteine and glutathione in plasma were not recovered by this treatment. In conclusion, the daily doses of NAC necessary for the total recuperation of plasma cysteine and glutathione levels in HIV-infected patients and the additional benefit
Disciplinas: Biología,
Medicina
Palabras clave: Biología celular,
Inmunología,
Terapéutica y rehabilitación,
N-acetilcisteína,
Apoptosis,
Viabilidad,
VIH,
Glutatión,
TNF alfa,
IL-8
Keyword: Biology,
Medicine,
Cell biology,
Immunology,
Therapeutics and rehabilitation,
N-acetylcysteine,
Apoptosis,
Viability,
HIV,
Glutathione,
IL-8
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