| Revista: | The brazilian journal of infectious diseases |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000290843 |
| ISSN: | 1413-8670 |
| Autors: | Treitinger, Aricio1 Spada, Celso Masokawa, Ivete Yoshico2 Silveira, Mariette Van Der Sander Luis, Magali Chaves Verdi, Julio Cesar Vidal3 Reis, Marcellus4 Ferreira, Silvia Ines Alejandra Cordova de Pires5 Abdalla, Dulcineia Saes Parra6 |
| Institucions: | 1Universidade Federal de Santa Catarina, Centro de Ciencias da Saude, Florianopolis, Santa Catarina. Brasil 2Hospital Nereu Ramos, Florianopolis, Santa Catarina. Brasil 3Secretaria da Saude, Florianopolis, Santa Catarina. Brasil 4Hospital da Universidade Federal de Santa Catarina, Florianopolis, Santa Catarina. Brasil 5Hemocentro de Santa Catarina, Florianopolis, Santa Catarina. Brasil 6Universidade de Sao Paulo, Sao Paulo. Brasil |
| Any: | 2004 |
| Període: | Oct |
| Volum: | 8 |
| Número: | 5 |
| Paginació: | 363-371 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Caso clínico |
| Resumen en inglés | N-acetyl-L-cysteine (NAC) has been proposed as an additional therapeutic agent for AIDS patients because it reduces human immunodeficiency virus type 1 (HIV-1) replication in stimulated CD4+ lymphocytes, and it ameliorates immunological reactivity. In a randomized, 180-day, double-blind, placebo-controlled trial performed with HIV-infected patients classified as A2 and A3 according to the criteria of the Center for Disease Control and Prevention, we investigated the effects of oral administration of NAC on HIV-infected patients undergoing their first anti-retroviral therapy; viral load, CD4+ lymphocyte, lymphocyte viability and apoptosis, and TNF-alpha and IL-8 levels were determined. Sixteen patients who received anti-retroviral therapy plus a placebo formed the control group and the study group consisted of 14 patients who received anti-retroviral therapy and NAC supplementation. A significant decrease was seen in viral load, TNF-alpha and IL-8 levels, and lymphocyte apoptosis, and a significant increase was found in levels of CD4+ lymphocytes and lymphocyte viability in both groups after anti-retroviral treatment, but no measurable benefits of anti-retroviral therapy plus NAC oral supplementation (600 mg/day) were found in relation to anti-retroviral therapy alone, and the baseline levels of cysteine and glutathione in plasma were not recovered by this treatment. In conclusion, the daily doses of NAC necessary for the total recuperation of plasma cysteine and glutathione levels in HIV-infected patients and the additional benefit |
| Disciplines | Biología, Medicina |
| Paraules clau: | Biología celular, Inmunología, Terapéutica y rehabilitación, N-acetilcisteína, Apoptosis, Viabilidad, VIH, Glutatión, TNF alfa, IL-8 |
| Keyword: | Biology, Medicine, Cell biology, Immunology, Therapeutics and rehabilitation, N-acetylcysteine, Apoptosis, Viability, HIV, Glutathione, IL-8 |
| Text complet: | Texto completo (Ver HTML) |
