| Revista: | Memorias do Instituto Oswaldo Cruz |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000446508 |
| ISSN: | 0074-0276 |
| Autores: | Soeiro, Maria de Nazaré Correia1 Vergoten, Gérard2 Bailly, Christian3 |
| Instituciones: | 1Fundacao Oswaldo Cruz, Instituto Oswaldo Cruz, Rio de Janeiro. Brasil 2Universite de Lille I, Institut de Chimie Pharmaceutique Albert Lespagnol, Lille, Cotes du Nord. Francia 3OncoWitan, Lille, Cotes du Nord. Francia |
| Año: | 2021 |
| Volumen: | 116 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | Extracts of the plant Glycyrrhiza glabra (licorice) are used in traditional medicine to treat malaria. The main active components are the saponin glycyrrhizin (GLR) and its active metabolite glycyrrhetinic acid (GA) which both display activities against Plasmodium falciparum. We have identified three main mechanisms at the origin of their anti-plasmodial activity: (i) drug-induced disorganisation of membrane lipid rafts, (ii) blockade of the alarmin protein HMGB1 and (iii) potential inhibition of the detoxifying enzyme glyoxalase 1 (GLO-1) considered as an important drug target for malaria. Our analysis shed light on the mechanism of action of GLR against P. falciparum |
| Disciplinas: | Medicina, Química |
| Palabras clave: | Fitoquímica, Bioquímica, Farmacología, Extractos vegetales, Acido glicirricínico, Actividad biológica, Plasmodium, Paludismo |
| Keyword: | Phytochemistry, Biochemistry, Pharmacology, Plant extracts, Glycyrrhizinic acid, Biological activity, Malaria, Plasmodium |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
