Seminal citrate is superior to PSA for detecting clinically significant prostate cancer



Título del documento: Seminal citrate is superior to PSA for detecting clinically significant prostate cancer
Revista: International braz j urol
Base de datos: PERIÓDICA
Número de sistema: 000434686
ISSN: 1677-5538
Autores: 1
2
3
3
2
Instituciones: 1Pontificia Universidade Catolica do Parana, Faculdade de Medicina, Londrina, Parana. Brasil
2Universidade Estadual de Londrina, Departamento de Cirurgia Clinica, Londrina, Parana. Brasil
3Universidade Estadual de Maringa, Departamento de Quimica, Maringa, Parana. Brasil
Año:
Periodo: Nov-Dic
Volumen: 45
Número: 6
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Analítico, descriptivo
Resumen en inglés Purpose: To establish whether the citrate concentration in the seminal fluid ([CITRATE]) measured by means of high-resolution nuclear magnetic resonance spectroscopy (1HNMRS) is superior to the serum prostate-specific antigen (PSA) concentration in detecting of clinically significant prostate cancer (csPCa) in men with persistently elevated PSA. Materials and Methods: The group of patients consisted of 31 consecutively seen men with histological diagnosis of clinically localized csPCa. The control group consisted of 28 men under long-term follow-up (mean of 8.7 ± 3.0 years) for benign prostate hyperplasia (BPH), with persistently elevated PSA (above 4 ng/mL) and several prostate biopsies negative for cancer (mean of 2.7 ± 1.3 biopsies per control). Samples of blood and seminal fluid (by masturbation) for measurement of PSA and citrate concentration, respectively, were collected from patients and controls. Citrate concentration in the seminal fluid ([CITRATE]) was determined by means of 1HNMRS. The capacities of PSA and [CITRATE] to predict csPCa were compared by means of univariate analysis and receiver operating characteristic (ROC) curves. Results: Median [CITRATE] was significantly lower among patients with csPCa compared to controls (3.93 mM/l vs. 15.53 mM/l). There was no significant difference in mean PSA between patients and controls (9.42 ng/mL vs. 8.57 ng/mL). The accuracy of [CITRATE] for detecting csPCa was significantly superior compared to PSA (74.8% vs. 54.8%). Conclusion: Measurement of [CITRATE] by means of 1HNMRS is superior to PSA for early detection of csPCa in men with elevated PSA
Disciplinas: Medicina
Palabras clave: Urología,
Oncología,
Diagnóstico,
Cáncer,
Próstata,
Marcadores diagnósticos,
Antígeno prostático específico,
Citratos
Keyword: Urology,
Oncology,
Diagnosis,
Cancer,
Prostate,
Diagnostic markers,
Prostate specific antigen,
Citrates
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