| Revista: | International braz j urol |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000434686 |
| ISSN: | 1677-5538 |
| Autors: | Gregório, Emerson Pereira1 Alexandrino, Antonio Paulo2 Schuquel, Ivania Terezinha Albrecht3 Costa, Willian Ferreira da3 Rodrigues, Marco Aurelio de Freitas2 |
| Institucions: | 1Pontificia Universidade Catolica do Parana, Faculdade de Medicina, Londrina, Parana. Brasil 2Universidade Estadual de Londrina, Departamento de Cirurgia Clinica, Londrina, Parana. Brasil 3Universidade Estadual de Maringa, Departamento de Quimica, Maringa, Parana. Brasil |
| Any: | 2019 |
| Període: | Nov-Dic |
| Volum: | 45 |
| Número: | 6 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | Purpose: To establish whether the citrate concentration in the seminal fluid ([CITRATE]) measured by means of high-resolution nuclear magnetic resonance spectroscopy (1HNMRS) is superior to the serum prostate-specific antigen (PSA) concentration in detecting of clinically significant prostate cancer (csPCa) in men with persistently elevated PSA. Materials and Methods: The group of patients consisted of 31 consecutively seen men with histological diagnosis of clinically localized csPCa. The control group consisted of 28 men under long-term follow-up (mean of 8.7 ± 3.0 years) for benign prostate hyperplasia (BPH), with persistently elevated PSA (above 4 ng/mL) and several prostate biopsies negative for cancer (mean of 2.7 ± 1.3 biopsies per control). Samples of blood and seminal fluid (by masturbation) for measurement of PSA and citrate concentration, respectively, were collected from patients and controls. Citrate concentration in the seminal fluid ([CITRATE]) was determined by means of 1HNMRS. The capacities of PSA and [CITRATE] to predict csPCa were compared by means of univariate analysis and receiver operating characteristic (ROC) curves. Results: Median [CITRATE] was significantly lower among patients with csPCa compared to controls (3.93 mM/l vs. 15.53 mM/l). There was no significant difference in mean PSA between patients and controls (9.42 ng/mL vs. 8.57 ng/mL). The accuracy of [CITRATE] for detecting csPCa was significantly superior compared to PSA (74.8% vs. 54.8%). Conclusion: Measurement of [CITRATE] by means of 1HNMRS is superior to PSA for early detection of csPCa in men with elevated PSA |
| Disciplines | Medicina |
| Paraules clau: | Urología, Oncología, Diagnóstico, Cáncer, Próstata, Marcadores diagnósticos, Antígeno prostático específico, Citratos |
| Keyword: | Urology, Oncology, Diagnosis, Cancer, Prostate, Diagnostic markers, Prostate specific antigen, Citrates |
| Text complet: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
