Revista: | Brazilian Journal of Pharmaceutical Sciences |
Base de datos: | PERIÓDICA |
Número de sistema: | 000451381 |
ISSN: | 1984-8250 |
Autores: | Jin, Qing Hao1 Fu, Zhi Yang1 Xia, Ya Nan1 Liu, Bing Yu1 Jiang, Hai Ying2 |
Instituciones: | 1Zhejiang Ocean University, Donghai Science and Technology College, Zhejiang, Zhoushan. China 2Jiaxing University, College of Medicine, Zhejiang, Jiaxing. China |
Año: | 2020 |
Volumen: | 56 |
País: | Brasil |
Idioma: | Inglés |
Tipo de documento: | Artículo |
Enfoque: | Experimental, aplicado |
Resumen en inglés | In the present study, a series of novel 5,7-diisoprenyloxyflavone derivatives were designed, synthesized, and evaluated for their antibacterial activity. Most of these compounds displayed significant antibacterial effects against Gram-positive bacteria, especially against strains of multidrug-resistant clinical isolates. Compounds 4c, 4g, 4i, 4j, 4k, 4l, 4n, 4q and 4t showed high levels of antimicrobial activity against Staphylococcus aureus RN4220 with minimum inhibitory concentrations of 4.0-20 µM. Compound 4k showed the most potent activity among these compounds against all multidrug-resistant clinical isolates tested. Unfortunately, none of the compounds were active against Gram-negative bacteria at the doses of 24-164 µM |
Disciplinas: | Química |
Palabras clave: | Química farmacéutica, Flavonoides, Síntesis química, Isopreniloxiflavonas, Actividad antibacteriana |
Keyword: | Medicinal chemistry, Flavonoids, Chemical synthesis, Isoprenyloxyflavones, Antibacterial activity |
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