Synthesis and antibacterial activity of a series novel 5,7-diisoprenyloxyflavone derivatives
Título del documento: Synthesis and antibacterial activity of a series novel 5,7-diisoprenyloxyflavone derivatives
Revista: Brazilian Journal of Pharmaceutical Sciences
Base de datos: PERIÓDICA
Número de sistema: 000451381
ISSN: 1984-8250
Autores: 1
1
1
1
2
Instituciones: 1Zhejiang Ocean University, Donghai Science and Technology College, Zhejiang, Zhoushan. China
2Jiaxing University, College of Medicine, Zhejiang, Jiaxing. China
Año:
Volumen: 56
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Experimental, aplicado
Resumen en inglés In the present study, a series of novel 5,7-diisoprenyloxyflavone derivatives were designed, synthesized, and evaluated for their antibacterial activity. Most of these compounds displayed significant antibacterial effects against Gram-positive bacteria, especially against strains of multidrug-resistant clinical isolates. Compounds 4c, 4g, 4i, 4j, 4k, 4l, 4n, 4q and 4t showed high levels of antimicrobial activity against Staphylococcus aureus RN4220 with minimum inhibitory concentrations of 4.0-20 µM. Compound 4k showed the most potent activity among these compounds against all multidrug-resistant clinical isolates tested. Unfortunately, none of the compounds were active against Gram-negative bacteria at the doses of 24-164 µM
Disciplinas: Química
Palabras clave: Química farmacéutica,
Flavonoides,
Síntesis química,
Isopreniloxiflavonas,
Actividad antibacteriana
Keyword: Medicinal chemistry,
Flavonoids,
Chemical synthesis,
Isoprenyloxyflavones,
Antibacterial activity
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