Improved antimutagenic effect of Pyrostegia venusta (Ker Gawl.) Miers nanostructured extract in liposome and polymeric nanoparticle



Título del documento: Improved antimutagenic effect of Pyrostegia venusta (Ker Gawl.) Miers nanostructured extract in liposome and polymeric nanoparticle
Revista: Brazilian Journal of Pharmaceutical Sciences
Base de datos: PERIÓDICA
Número de sistema: 000451720
ISSN: 1984-8250
Autores: 1
2
3
3
4
5
6
1
Instituciones: 1Universidade Federal de Mato Grosso, Programa de Pos-graduacao em Ciencias Ambientais, Sinop, Mato Grosso. Brasil
2Universidade Federal de Mato Grosso, Programa de Pos-graduacao em Ciencias da Saude, Sinop, Mato Grosso. Brasil
3Universidade Federal de Santa Maria, Centro de Ciencias da Saude, Santa Maria, Rio Grande do Sul. Brasil
4Empresa Brasileira de Pesquisa Agropecuaria, Sinop, Mato Grosso. Brasil
5Universidade Federal de Mato Grosso, Instituto de Ciencias Naturais, Humanas e Sociais, Sinop, Mato Grosso. Brasil
6Universidade Federal do Piaui, Departamento de Quimica, Teresina, Piaui. Brasil
Año:
Volumen: 58
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Experimental, aplicado
Resumen en inglés Pyrostegia venusta (Ker Gawl.) Miers, popularly known as “Cipó-de São-João”, has been used in traditional medicine for its therapeutic properties. Nanotechnology is able to enhance the pharmacological activity of plant extracts. In this context, liposomes and polymeric nanoparticles containing P. venusta ethanolic extract were developed and then physico-chemically characterized to evaluate the mutagenic/antimutagenic effects of P. venusta. In addition, transaminases and serum creatinine were biochemically analyzed for liver and renal damage, respectively. The micronucleus test was performed with male Swiss mice treated orally for 15 consecutive days with free extracts and nanostructured with P. venusta, and then intraperitoneally with N-ethyl-N-nitrosurea (50 mg/kg) on the 15th day of treatment. Micronucleated polychromatic erythrocytes (MNPCE) were evaluated in bone marrow. There was a significant reduction in the frequency of MNPCE (LPEPV = 183% and NPEPV = 114%, p < 0.001), indicating antimutagenic potential of the nanostructured extracts with P. venusta. The groups treated with only nanostructured extract did not show an increase in MNPCE frequency, and biochemical analyzes showed no significant difference between treatments. The liposomes and polymeric nanoparticles containing Pyrostegia venusta ethanolic extract showed biological potential in preventing the first step of carcinogenesis under the experimental conditions
Disciplinas: Biología,
Química
Palabras clave: Fitoquímica,
Angiospermas,
Plantas medicinales,
Flavonoides,
Prueba de micronúcleos,
Pyrostegia venusta,
Bignoniaceae
Keyword: Phytochemistry,
Angiosperms,
Medicinal plants,
Flavonoids,
Micronucleus test,
Pyrostegia venusta,
Bignoniaceae
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