| Revista: | Brazilian Journal of Pharmaceutical Sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000451720 |
| ISSN: | 1984-8250 |
| Autors: | Zanco, Patrícia1 Ferrarini, Stela Regina2 Cruz, Letícia3 Ferreira, Luana Mota3 Bicudo, Rogério de Campos4 Cavalheiro, Larissa5 Vieira, Gerardo Magela6 Sugui, Marina Mariko1 |
| Institucions: | 1Universidade Federal de Mato Grosso, Programa de Pos-graduacao em Ciencias Ambientais, Sinop, Mato Grosso. Brasil 2Universidade Federal de Mato Grosso, Programa de Pos-graduacao em Ciencias da Saude, Sinop, Mato Grosso. Brasil 3Universidade Federal de Santa Maria, Centro de Ciencias da Saude, Santa Maria, Rio Grande do Sul. Brasil 4Empresa Brasileira de Pesquisa Agropecuaria, Sinop, Mato Grosso. Brasil 5Universidade Federal de Mato Grosso, Instituto de Ciencias Naturais, Humanas e Sociais, Sinop, Mato Grosso. Brasil 6Universidade Federal do Piaui, Departamento de Quimica, Teresina, Piaui. Brasil |
| Any: | 2022 |
| Volum: | 58 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | Pyrostegia venusta (Ker Gawl.) Miers, popularly known as “Cipó-de São-João”, has been used in traditional medicine for its therapeutic properties. Nanotechnology is able to enhance the pharmacological activity of plant extracts. In this context, liposomes and polymeric nanoparticles containing P. venusta ethanolic extract were developed and then physico-chemically characterized to evaluate the mutagenic/antimutagenic effects of P. venusta. In addition, transaminases and serum creatinine were biochemically analyzed for liver and renal damage, respectively. The micronucleus test was performed with male Swiss mice treated orally for 15 consecutive days with free extracts and nanostructured with P. venusta, and then intraperitoneally with N-ethyl-N-nitrosurea (50 mg/kg) on the 15th day of treatment. Micronucleated polychromatic erythrocytes (MNPCE) were evaluated in bone marrow. There was a significant reduction in the frequency of MNPCE (LPEPV = 183% and NPEPV = 114%, p < 0.001), indicating antimutagenic potential of the nanostructured extracts with P. venusta. The groups treated with only nanostructured extract did not show an increase in MNPCE frequency, and biochemical analyzes showed no significant difference between treatments. The liposomes and polymeric nanoparticles containing Pyrostegia venusta ethanolic extract showed biological potential in preventing the first step of carcinogenesis under the experimental conditions |
| Disciplines | Biología, Química |
| Paraules clau: | Fitoquímica, Angiospermas, Plantas medicinales, Flavonoides, Prueba de micronúcleos, Pyrostegia venusta, Bignoniaceae |
| Keyword: | Phytochemistry, Angiosperms, Medicinal plants, Flavonoids, Micronucleus test, Pyrostegia venusta, Bignoniaceae |
| Text complet: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
