Effects of sodium nitroprusside in the prevention of schizophrenia-like symptoms induced by ketamine – A translational double-blind study



Título del documento: Effects of sodium nitroprusside in the prevention of schizophrenia-like symptoms induced by ketamine – A translational double-blind study
Revista: Archives of clinical psychiatry
Base de datos: PERIÓDICA
Número de sistema: 000413935
Autores: 1
2
1
1
1
1
3
3
1
2
2
1
Instituciones: 1Universidade de Sao Paulo, Faculdade de Medicina de Ribeirao Preto, Ribeirao Preto, Sao Paulo. Brasil
2Universidade Federal do Rio Grande do Sul, Instituto Nacional de Ciencia e Tecnologia Translacional em Medicina, Porto Alegre, Rio Grande do Sul. Brasil
3Universidade Federal de Sao Paulo, Escola Paulista de Medicina, Sao Paulo. Brasil
Año:
Periodo: Nov-Dic
Volumen: 44
Número: 6
Paginación: 148-153
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Analítico, descriptivo
Resumen en inglés Recent evidence has shown improvements in schizophrenia symptoms after the infusion of sodium nitroprusside (SNP), a nitric oxide (NO) donor. In the rat model of schizophrenia using ketamine injection, pretreatment with SNP seems to prevent behavioral changes associated with positive symptoms for up to one week. Objective: We investigated whether SNP would have preventative effects on psychogenic symptoms induced by ketamine in healthy subjects. Methods: Healthy subjects (N = 38) were assigned to distinct groups that received SNP in different doses (0.15, 0.25, and 0.5 mcg/kg/min). First, participants received an infusion of SNP or placebo over 75 minutes. After 10 minutes, they were injected for 1 minute with a bolus of 0.26 mg/kg of ketamine and a maintenance dose was started 5 minutes later, with 0.25 mg/kg/h of ketamine for 50 minutes. Results: Ketamine-induced psychopathological alterations induced were reduced by SNP, as assessed with the Brief Psychological Rating Scale. Scores in the objective subscale of the Clinician-Administered Dissociative States Scale were also lower in SNP sessions compared to placebo. SNP had protective effects against deterioration in facial emotion and identity recognition tasks induced by ketamine. Discussion: Our findings support the view that SNP has preventative properties against psychotic manifestations
Disciplinas: Medicina
Palabras clave: Farmacología,
Psiquiatría,
Psicosis,
Esquizofrenia,
Nitroprusiato de sodio,
Oxido nítrico,
Ketamina
Keyword: Medicine,
Pharmacology,
Psychiatry,
Psychosis,
Schizophrenia,
Sodium nitroprusside,
Nitric oxide,
Ketamine
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