| Revista: | Archives of clinical psychiatry |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000413935 |
| Autors: | Rezende, Tatiana M.N1 Maia de Oliveira, Joao Paulo2 Kandratavicius, Ludmyla1 Machado de Sousa, Joao Paulo1 Abrao, Joao1 Prado, Daniel Almeida1 Bressan, Rodrigo A3 Lacerda, Acioly L.T3 Zuardi, Antonio W1 Baker, Glen B2 Dursun, Serdar M2 Hallak, Jaime E.C1 |
| Institucions: | 1Universidade de Sao Paulo, Faculdade de Medicina de Ribeirao Preto, Ribeirao Preto, Sao Paulo. Brasil 2Universidade Federal do Rio Grande do Sul, Instituto Nacional de Ciencia e Tecnologia Translacional em Medicina, Porto Alegre, Rio Grande do Sul. Brasil 3Universidade Federal de Sao Paulo, Escola Paulista de Medicina, Sao Paulo. Brasil |
| Any: | 2017 |
| Període: | Nov-Dic |
| Volum: | 44 |
| Número: | 6 |
| Paginació: | 148-153 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | Recent evidence has shown improvements in schizophrenia symptoms after the infusion of sodium nitroprusside (SNP), a nitric oxide (NO) donor. In the rat model of schizophrenia using ketamine injection, pretreatment with SNP seems to prevent behavioral changes associated with positive symptoms for up to one week. Objective: We investigated whether SNP would have preventative effects on psychogenic symptoms induced by ketamine in healthy subjects. Methods: Healthy subjects (N = 38) were assigned to distinct groups that received SNP in different doses (0.15, 0.25, and 0.5 mcg/kg/min). First, participants received an infusion of SNP or placebo over 75 minutes. After 10 minutes, they were injected for 1 minute with a bolus of 0.26 mg/kg of ketamine and a maintenance dose was started 5 minutes later, with 0.25 mg/kg/h of ketamine for 50 minutes. Results: Ketamine-induced psychopathological alterations induced were reduced by SNP, as assessed with the Brief Psychological Rating Scale. Scores in the objective subscale of the Clinician-Administered Dissociative States Scale were also lower in SNP sessions compared to placebo. SNP had protective effects against deterioration in facial emotion and identity recognition tasks induced by ketamine. Discussion: Our findings support the view that SNP has preventative properties against psychotic manifestations |
| Disciplines | Medicina |
| Paraules clau: | Farmacología, Psiquiatría, Psicosis, Esquizofrenia, Nitroprusiato de sodio, Oxido nítrico, Ketamina |
| Keyword: | Medicine, Pharmacology, Psychiatry, Psychosis, Schizophrenia, Sodium nitroprusside, Nitric oxide, Ketamine |
| Text complet: | Texto completo (Ver HTML) |
