Interferon-tau polymorphisms and their potential functions in ruminants



Título del documento: Interferon-tau polymorphisms and their potential functions in ruminants
Revista: ARBS. Annual review of biomedical sciences
Base de datos: PERIÓDICA
Número de sistema: 000270149
ISSN: 1678-4618
Autores: 1

Instituciones: 1University of Florida, Department of Animal Sciences, Gainesville, Florida. Estados Unidos de América
Año:
Volumen: 8
Paginación: 9-18
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Analítico
Resumen en inglés In ruminants, the establishment and maintenance of pregnancy requires production of a Type I interferon, termed IFN-ô. This protein is synthesized by the developing conceptus and interacts with the uterus to promote continued secretion of progesterone. Multiple genes encode IFN-ô, and a majority of these genes are transcribed during early pregnancy. The proteins possess divergent biological activities, including the ability to prevent the corpus luteum from regressing at the end of a normal estrous cycle. In all likelihood multiple IFN-ô isoforms are produced during early pregnancy to ensure that sufficient quantities of bioactive IFN-ô are present to modulate uterine biology during early pregnancy. Although IFN-ô has evolved to serve as the pregnancy recognition hormone in ruminants, other Type I IFNs, such as IFN-á and IFN-ù, are capable of producing a uterine response similar to that of IFN-ô. Hence, the polymorphic nature of IFN-ô genes appear to have generated new and potentially more active forms of the hormone, but the unique expression pattern for IFN-ô is likely the preeminent feature ensuring its use as the maternal recognition of pregnancy factor in ruminants
Disciplinas: Medicina veterinaria y zootecnia,
Medicina
Palabras clave: Medicina veterinaria,
Endocrinología,
Interferón,
Placenta,
Endometrio,
Polimorfismo,
Embriones,
Rumiantes,
Gestación
Keyword: Veterinary medicine and animal husbandry,
Medicine,
Veterinary medicine,
Endocrinology,
Interferon,
Placenta,
Endometrium,
Polymorphism,
Embryos,
Ruminants,
Gestation
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