| Revista: | ARBS. Annual review of biomedical sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000270149 |
| ISSN: | 1678-4618 |
| Autores: | Ealy, Alan D1 Pennington, Kathleen A Rodina, Teresa M |
| Instituciones: | 1University of Florida, Department of Animal Sciences, Gainesville, Florida. Estados Unidos de América |
| Año: | 2006 |
| Volumen: | 8 |
| Paginación: | 9-18 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico |
| Resumen en inglés | In ruminants, the establishment and maintenance of pregnancy requires production of a Type I interferon, termed IFN-ô. This protein is synthesized by the developing conceptus and interacts with the uterus to promote continued secretion of progesterone. Multiple genes encode IFN-ô, and a majority of these genes are transcribed during early pregnancy. The proteins possess divergent biological activities, including the ability to prevent the corpus luteum from regressing at the end of a normal estrous cycle. In all likelihood multiple IFN-ô isoforms are produced during early pregnancy to ensure that sufficient quantities of bioactive IFN-ô are present to modulate uterine biology during early pregnancy. Although IFN-ô has evolved to serve as the pregnancy recognition hormone in ruminants, other Type I IFNs, such as IFN-á and IFN-ù, are capable of producing a uterine response similar to that of IFN-ô. Hence, the polymorphic nature of IFN-ô genes appear to have generated new and potentially more active forms of the hormone, but the unique expression pattern for IFN-ô is likely the preeminent feature ensuring its use as the maternal recognition of pregnancy factor in ruminants |
| Disciplinas: | Medicina veterinaria y zootecnia, Medicina |
| Palabras clave: | Medicina veterinaria, Endocrinología, Interferón, Placenta, Endometrio, Polimorfismo, Embriones, Rumiantes, Gestación |
| Keyword: | Veterinary medicine and animal husbandry, Medicine, Veterinary medicine, Endocrinology, Interferon, Placenta, Endometrium, Polymorphism, Embryos, Ruminants, Gestation |
| Texto completo: | Texto completo (Ver PDF) |
