EGFR inhibitors: clinical aspects, risk factors and biomarkers for acneiform eruptions and other mucosal and cutaneous adverse effects
Título del documento: EGFR inhibitors: clinical aspects, risk factors and biomarkers for acneiform eruptions and other mucosal and cutaneous adverse effects
Revista: Anais brasileiros de dermatologia
Base de datos: PERIÓDICA
Número de sistema: 000460523
ISSN: 0365-0596
Autores: 1
2
1
1
Instituciones: 1Universidade Federal de Ciencias da Saude de Porto Alegre, Programa de Pos–Graduacao em Patologia, Porto Alegre, Rio Grande do Sul. Brasil
2Irmandade Santa Casa de Misericordia de Porto Alegre, Servico de Dermatologia, Porto Alegre, Rio Grande do Sul. Brasil
Año:
Periodo: Jul-Ago
Volumen: 98
Número: 4
Paginación: 429-439
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Analítico, descriptivo
Resumen en inglés The frequency of the use of drugs that act on the epidermal growth factor receptor (EGFR) is increasing, with the consequent onset of cutaneous toxicity, specifically acneiform eruption. The authors extensively review the topic, focusing on describing how these drugs can affect the skin and its appendages, that is, the pathophysiology that encompasses the cutaneous toxicity related to the use of EGFR inhibitors. In addition, it was possible to list the risk factors that may be associated with adverse effects of these drugs. Based on this recent knowledge, the authors expect to aid in the management of patients who are more vulnerable to toxicity, reduce morbidities, and improve the quality of life of patients undergoing treatment with EGFR inhibitors. Other issues related to the toxicity of EGFR inhibitors, such as the clinical aspects of the acneiform eruption grades, and other different types of cutaneous and mucosal reactions, are also included in the article
Disciplinas: Medicina
Palabras clave: Farmacología,
Dermatología,
Erupción cutánea,
Acné,
Fármacos,
Factor de crecimiento epidérmico,
Blancos terapéuticos,
Factores de riesgo,
Efectos adversos
Keyword: Pharmacology,
Dermatology,
Cutaneous eruption,
Acne,
Drugs,
Epidermal growth factor,
Side effects,
Risk factors,
Therapeutic targets
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