| Revista: | Revista do Instituto de Medicina Tropical de Sao Paulo |
| Base de datos: | |
| Número de sistema: | 000547881 |
| ISSN: | 0036-4665 |
| Autores: | Oliveira, Beatriz Araujo1 Oliveira, Lea Campos de1 Oliveira, Franciane Mendes de1 Pereira, Geovana Maria1 Souza, Regina Maia de1 Manuli, Erika Regina1 Marchini, Fabricio Klerynton2 Espinoza, Evelyn Patrícia Sanchez1 Park, Marcelo1 Taniguchi, Leandro1 Mendes, Pedro Vitale1 Franco, Lucas Augusto Moyses1 Nastri, Ana Catharina1 Oliveira, Maura Salaroli de1 Vieira Junior, José Mauro3 Kallas, Esper Georges1 Levin, Anna Sara1 Sabino, Ester Cerdeira1 Costa, Silvia Figueiredo1 |
| Instituciones: | 1Universidade de São Paulo, Faculdade de Medicina, São Paulo. Brasil 2Fundação Oswaldo Cruz, Instituto Carlos Chagas, Curitiba, Paraná. Brasil 3Hospital Sírio Libanês, Unidade de Terapia Intensiva, São Paulo. Brasil |
| Año: | 2022 |
| Volumen: | 64 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Resumen en inglés | COVID-19 disease is spread worldwide and diagnostic techniques have been studied in order to contain the pandemic. Immunochromatographic (IC) assays are feasible and a low-cost alternative especially in low and middle-income countries, which lack structure to perform certain diagnostic techniques. Here we evaluate the sensitivity and specificity of eleven different IC tests in 145 serum samples from confirmed cases of COVID-19 using RT-PCR and 100 negative serum samples from blood donors collected in February 2019. We also evaluated the cross-reactivity with dengue using 20 serum samples from patients with confirmed diagnosis for dengue collected in early 2019 through four different tests. We found high sensitivity (92%), specificity (100%) and an almost perfect agreement (Kappa 0.92) of IC assay, especially when we evaluated IgG and IgM combined after 10 days from the onset of symptoms with RT-PCR. However, we detected cross-reactivity between dengue and COVID-19 mainly with IgM antibodies (5 to 20% of cross-reaction) and demonstrated the need for better studies about diagnostic techniques for these diseases. |
| Disciplinas: | Medicina, Medicina, Biología |
| Palabras clave: | Diagnóstico, Neumología, Virus |
| Keyword: | Diagnosis, Pneumology, Virus |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
