Malnutrition and Associated Motor and Non-motor Factors in People with Parkinson's Disease



Título del documento: Malnutrition and Associated Motor and Non-motor Factors in People with Parkinson's Disease
Revista: Revista de investigación clínica
Base de datos: PERIÓDICA
Número de sistema: 000453202
ISSN: 0034-8376
Autores: 1
2
3
3
3
3
Instituciones: 1Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Departamento de Neurología, Ciudad de México. México
2Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Clínica de Trastornos del Movimiento, Ciudad de México. México
3Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Unidad de Investigación Clínica Neurodegenerativa, Ciudad de México. México
Año:
Periodo: Sep-Oct
Volumen: 72
Número: 5
Paginación: 293-299
País: México
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Analítico, descriptivo
Resumen en inglés Background: People with Parkinson’s disease (PwP) are at higher risk of developing malnutrition. Several factors have been suggested to be involved including motor symptoms, non-motor symptoms, and treatment-related complications. Objective: The objective of the study was to analyze the combined effect of motor, non-motor, and pharmacological factors in the risk of malnutrition in PwP. Methods: Eighty-seven consecutive PwP were included in the study. Clinical data and pharmacological treatment were collected. Nutritional status was assessed using the Mini-Nutritional Assessment (MNA) questionnaire. Movement Disorder Society Unified Parkinson’s Disease Rating Scale (MDS-UPDRS), Non-motor Symptoms Scale (NMSS), Hamilton Depression Rating Scale HAM-D, and Montreal Cognitive Assessment were applied. Results: Thirty (34.4%) PwP were at risk of malnutrition and seven had malnutrition (8%). Abnormal nutritional status was associated with lower education, higher MDS-UPDRS Parts I, II, and III and total scores, and higher scores in the NMSS domain of sleep disorders and fatigue. MDS-UPDRS motor score remained as a determinant of abnormal nutritional status, defined as MNA <23.5, with an odds ratio 1.1 (95% confidence interval 1.01-1.10, p = 0.02). Conclusion: The main factor associated with nutritional status was severity of the motor symptoms as assessed by the MDS-UPDRS Part III. Non-motor symptoms and treatment-related complications were not associated with malnutrition
Disciplinas: Medicina
Palabras clave: Neurología,
Metabolismo y nutrición,
Enfermedad de Parkinson,
Desnutrición,
Síntomas motores,
Depresión,
Demencia
Keyword: Neurology,
Metabolism and nutrition,
Parkinson disease,
Malnutrition,
Motor symptoms,
Depression,
Dementia
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