| Revista: | Memorias do Instituto Oswaldo Cruz |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000413858 |
| ISSN: | 0074-0276 |
| Autores: | Antonio, Liliane de Fatima1 Lyra, Marcelo Rosandiski1 Saheki, Mauricio Naoto1 Schubach, Armando de Oliveira1 Miranda, Luciana de Freitas Campos1 Madeira, Maria de Fatima1 Lourenco, Maria Cristina da Silva1 Fagundes, Aline1 Ribeiro, Erica Aparecida dos Santos1 Barreto, Leonardo1 Pimentel, Maria Ines Fernandes1 |
| Instituciones: | 1Fundacao Oswaldo Cruz, Instituto Nacional de Infectologia Evandro Chagas, Rio de Janeiro. Brasil |
| Año: | 2017 |
| Periodo: | Sep |
| Volumen: | 112 |
| Número: | 9 |
| Paginación: | 640-646 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | Cutaneous leishmaniasis (CL) generally presents with a single or several localised cutaneous ulcers without involvement of mucous membranes. Ulcerated lesions are susceptible to secondary contamination that may slow the healing process. OBJECTIVE This study verified the influence of non-parasitic wound infection on wound closure (epithelialisation) and total healing. METHODS Twenty-five patients with a confirmed diagnosis of CL and ulcerated lesions underwent biopsy of ulcer borders. One direct microbial parameter (germ identification in cultures) and four indirect clinical parameters (secretion, pain, burning sensation, pruritus) were analysed. FINDINGS Biopsies of ten lesions showed secondary infection by one or two microorganisms (Staphylococcus aureus, Pseudomonas aeruginosa, Enterococcus faecalis, Streptococcus pyogenes and Candida parapsilosis). “Secretion” and “burning sensation” influenced epithelialisation time but not total healing time. Positive detection of germs in the ulcer border and “pain” and “pruritus” revealed no influence on wound closure. CONCLUSIONS Our borderline proof of clinical CL ulcer infection inhibiting CL wound healing supports the need to follow antimicrobial stewardship in CL ulcer management, which was recently proposed for all chronic wounds |
| Disciplinas: | Medicina |
| Palabras clave: | Dermatología, Parasitología, Ulceras dérmicas, Infecciones oportunistas, Leishmaniasis cutánea |
| Keyword: | Medicine, Dermatology, Parasitology, Skin ulcers, Opportunistic infections, Cutaneous leishmaniasis |
| Texto completo: | Texto completo (Ver HTML) |
