Effect of secondary infection on epithelialisation and total healing of cutaneous leishmaniasis lesions



Document title: Effect of secondary infection on epithelialisation and total healing of cutaneous leishmaniasis lesions
Journal: Memorias do Instituto Oswaldo Cruz
Database: PERIÓDICA
System number: 000413858
ISSN: 0074-0276
Authors: 1
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Institutions: 1Fundacao Oswaldo Cruz, Instituto Nacional de Infectologia Evandro Chagas, Rio de Janeiro. Brasil
Year:
Season: Sep
Volumen: 112
Number: 9
Pages: 640-646
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Experimental, aplicado
English abstract Cutaneous leishmaniasis (CL) generally presents with a single or several localised cutaneous ulcers without involvement of mucous membranes. Ulcerated lesions are susceptible to secondary contamination that may slow the healing process. OBJECTIVE This study verified the influence of non-parasitic wound infection on wound closure (epithelialisation) and total healing. METHODS Twenty-five patients with a confirmed diagnosis of CL and ulcerated lesions underwent biopsy of ulcer borders. One direct microbial parameter (germ identification in cultures) and four indirect clinical parameters (secretion, pain, burning sensation, pruritus) were analysed. FINDINGS Biopsies of ten lesions showed secondary infection by one or two microorganisms (Staphylococcus aureus, Pseudomonas aeruginosa, Enterococcus faecalis, Streptococcus pyogenes and Candida parapsilosis). “Secretion” and “burning sensation” influenced epithelialisation time but not total healing time. Positive detection of germs in the ulcer border and “pain” and “pruritus” revealed no influence on wound closure. CONCLUSIONS Our borderline proof of clinical CL ulcer infection inhibiting CL wound healing supports the need to follow antimicrobial stewardship in CL ulcer management, which was recently proposed for all chronic wounds
Disciplines: Medicina
Keyword: Dermatología,
Parasitología,
Ulceras dérmicas,
Infecciones oportunistas,
Leishmaniasis cutánea
Keyword: Medicine,
Dermatology,
Parasitology,
Skin ulcers,
Opportunistic infections,
Cutaneous leishmaniasis
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