Intercepting biological messages: Antibacterial molecules targeting nucleic acids during interbacterial conflicts



Título del documento: Intercepting biological messages: Antibacterial molecules targeting nucleic acids during interbacterial conflicts
Revista: Genetics and molecular biology
Base de datos: PERIÓDICA
Número de sistema: 000459164
ISSN: 1415-4757
Autores: 1
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1
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Instituciones: 1Universidade de Sao Paulo, Instituto de Ciencias Biomedicas, Sao Paulo. Brasil
Año:
Volumen: 46
Número: 1
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Descriptivo
Resumen en inglés Bacteria live in polymicrobial communities and constantly compete for resources. These organisms have evolved an array of antibacterial weapons to inhibit the growth or kill competitors. The arsenal comprises antibiotics, bacteriocins, and contact-dependent effectors that are either secreted in the medium or directly translocated into target cells. During bacterial antagonistic encounters, several cellular components important for life become a weak spot prone to an attack. Nucleic acids and the machinery responsible for their synthesis are well conserved across the tree of life. These molecules are part of the information flow in the central dogma of molecular biology and mediate long- and short-term storage for genetic information. The aim of this review is to summarize the diversity of antibacterial molecules that target nucleic acids during antagonistic interbacterial encounters and discuss their potential to promote the emergence antibiotic resistance
Disciplinas: Biología
Palabras clave: Genética,
Bacterias,
Antibióticos,
Revisión bibliográfica,
Moléculas antibacterianas
Keyword: Genetics,
Bacteria,
Antibiotics,
Bibliographic review,
Antibacterial molecules
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