Effect of ACTH4-10pro8-gly9-pro10 on malondialdehyde and F2-isoprostane 15(S)-8-iso-PGF2a expression in rat spinal cord injury
Título del documento: Effect of ACTH4-10pro8-gly9-pro10 on malondialdehyde and F2-isoprostane 15(S)-8-iso-PGF2a expression in rat spinal cord injury
Revista: Gaceta médica de Caracas
Base de datos:
Número de sistema: 000595987
ISSN: 2739-0012
Autores: 1
1
1
2
1
1
3
Instituciones: 1Department of Neurosurgery, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia,
2Department of Public Health and Preventive Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia,
3Faculty of Medicine, Universitas Nahdlatul Ulama Surabaya, Surabaya, Indonesia,
Año:
Volumen: 131
Número: 4
País: Venezuela
Idioma: Español
Resumen en español Background: Spinal cord injury (SCI) is damage to the spinal cord caused mainly by trauma resulting in major motor, sensory, and autonomic dysfunctions. This experimental study aims to assess the effect of ACTH4-10Pro8-Gly9-Pro10 administration in rats with mild and severe compression injuries on the levels of malondialdehyde and F2-isoprostane 15(S)-8-iso-PGF2α levels. Methods: Mild and severe spinal cord compression was performed on 27 subjects. They were divided into three groups of samples with control included, 3 and 6 h after the injury.
Palabras clave: ACTH4-10Pro8 -Gly9 -Pro10,
spinal cord injury,
reactive oxygen species,
malondialdehyde,
F2-isoprostane
Texto completo: Texto completo (Ver PDF) Texto completo (Ver HTML)