| Revista: | Anais da Academia Brasileira de Ciencias |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000435967 |
| ISSN: | 0001-3765 |
| Autores: | Núñez, Jisette G1 Pinheiro, Jordania S1 Padilha, Gustavo L2 Garcia, Helana O1 Porta, Vitória1 Apel, Miriam A3 Bruno, Alessandra N1 |
| Instituciones: | 1Instituto Federal de Educacao, Ciencia e Tecnologia do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul. Brasil 2Universidade Federal do Rio Grande do Sul, Faculdade de Farmacia, Porto Alegre, Rio Grande do Sul. Brasil 3Universidade Federal de Ciencias da Saude de Porto Alegre, Porto Alegre, Rio Grande do Sul. Brasil |
| Año: | 2020 |
| Volumen: | 92 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | Breast and cervical cancer represent a major problem of women’s global public health. Here, we investigated the chemical composition of essential oils from leaves and flowers of T. ostenii and the antineoplastic potential in a cervical cancer and breast cancer cell line, SiHa and MCF-7; and non-tumoral cells, HaCat. The chemical analysis revealed a predominance of oxygenated monoterpenes in both essential oils. The IC50 after 24 h of treatment was 72 ng/mL for EO 1 and 83 ng/mL for EO 2 in SiHa cells. For MCF-7 the IC50 was 174.3 ng/mL for EO 1. For HaCat cells it was 54.45 ng/mL for EO 1 and 20.83 ng/mL for EO 2. A synergistic effect with both essential oils and cisplatin was also verified. SiHa cells had their wound healing capacity reduced after 48 h of treatment with EO 2 and both essential oils were able to significantly inhibit the adhesion process and clonogenic ability after 24 h of treatment. Our results suggest a long-lasting inhibitory activity in SiHa cells because of the low recovery capacity of cells after treatment withdrawal. Flow cytometer with annexin V/propidium iodide demonstrated a majority cell death through late apoptosis after 24, 48 and 72 hours of treatment |
| Disciplinas: | Medicina, Química |
| Palabras clave: | Fitoquímica, Farmacología, Oncología, Aceites esenciales, Composición química, Actividad antineoplásica, Cáncer cervical, Citotoxicidad, Tagetes ostenii, Compositae |
| Keyword: | Phytochemistry, Pharmacology, Oncology, Essential oils, Chemical composition, Antineoplastic activity, Cervical cancer, Cytotoxicity, Tagetes ostenii, Compositae |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
