| Revista: | Genetics and molecular biology |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000459188 |
| ISSN: | 1415-4757 |
| Autors: | Feng, Wen1 Zhou, Lei1 Du, Heng1 Okoth, Edward2 Mrode, Raphael2 Jin, Wenjiao1 Hu, Zhengzheng1 Liu, Jian-Feng1 |
| Institucions: | 1State Key Laboratory of Animal Biotech Breeding, Beijing. China 2International Livestock Research Institute, Nairobi. Kenia |
| Any: | 2023 |
| Volum: | 46 |
| Número: | 3 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | African swine fever (ASF) is an important viral disease of swine caused by the African swine fever virus (ASFV), which threatens swine production profoundly. To better understand the gene expression changes when pig infected with ASFV, RNA sequencing was performed to characterize differentially expressed genes (DEGs) of six tissues from Kenya domestic pigs and Landrace × Yorkshire (L/Y) pigs infected with ASFV Kenya1033 in vivo. As results, a total of 209, 522, 34, 505, 634 and 138 DEGs (q-value < 0.05 and |Log2foldchange| values >2) were detected in the kidney, liver, mesenteric lymph node, peripheral blood mononuclear cell, submandibular lymph node and spleen, respectively. The expression profiles of DEGs shared in the multiple tissues illustrated variation in regulation function in the different tissues. Functional annotation analysis and interaction of proteins encoded by DEGs revealed that genes including IFIT1, IFITM1, MX1, OASL, ISG15, SAMHD1, IFINA1, S100A12 and S100A8 enriched in the immune and antivirus pathways were significantly changed when the hosts were infected with ASFV. The genes mentioned could play crucial roles in the process of the reaction to non-lethal ASF infection, which may will help to improve the ASF tolerance in the pig population through molecular breeding strategies |
| Disciplines | Biología |
| Paraules clau: | Porcinos, Virus, Genética, Peste porcina africana, Transcriptoma, Expresión génica |
| Keyword: | Swine, Virus, Genetics, Swine fever-african, Transcriptome, Gene expression |
| Text complet: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
