The influence of the moisture content of microcrystalline cellulose on the coating process in a fluidized bed



Título del documento: The influence of the moisture content of microcrystalline cellulose on the coating process in a fluidized bed
Revista: Brazilian journal of chemical engineering
Base de datos: PERIÓDICA
Número de sistema: 000308948
ISSN: 0104-6632
Autors: 1

Institucions: 1Universidade Estadual de Campinas, Faculdade de Engenharia Quimica, Campinas, Sao Paulo. Brasil
Any:
Període: Jun
Volum: 21
Número: 2
Paginació: 325-333
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Experimental, aplicado
Resumen en inglés The objective of this work was to study the coating of microcrystalline cellulose with a polymeric suspension in a fluidized bed. The coating operation was carried out using a fluidized bed with top spraying by a double-fluid nozzle. The fluidized bed consists of a cylindrical column made of plexiglass with a height of 0.6 m and an inner diameter of 0.14 m. The polymeric coating suspension was formulated using Eudragit® as the basic component. As the quality of the coating product is greatly affected by the spraying characteristics, the influence of the flow rate of the coating suspension and the moisture content of the particles on the agglomeration index and efficiency of the process of coating microcrystalline cellulose was analyzed
Disciplines Química
Paraules clau: Química farmacéutica,
Ingeniería química,
Celulosa microcristalina,
Contenido de humedad,
Recubrimiento,
Fluidización
Keyword: Chemistry,
Medicinal chemistry,
Chemical engineering,
Microcrystalline cellulose,
Moisture content,
Coating,
Fluidization
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