| Revista: | Biocell |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000324473 |
| ISSN: | 0327-9545 |
| Autors: | Joubert, Annie1 Van Zyl, Hermia1 Laurens, Johannes2 Lottering, Mona-Liza1 |
| Institucions: | 1University of Pretoria, Department of Physiology, Pretoria, Transvaal. Sudáfrica 2University of Pretoria, Department of Chemistry, Pretoria, Transvaal. Sudáfrica |
| Any: | 2009 |
| Període: | Dic |
| Volum: | 33 |
| Número: | 3 |
| Paginació: | 137-140 |
| País: | Argentina |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | C2- and C4-position 17β-estradiol metabolites play an important role in breast carcinogenesis. 2-Hydroxyestradiol and 4-hydroxyestradiol are implicated in tumorigenesis via two pathways. These pathways entail increased cell proliferation and the formation of reactive oxygen species that trigger an increase in the likelihood of deoxyribonucleic acid mutations. 2-Methoxyestradiol, a 17β-estradiol metabolite, however, causes induction of apoptosis in transformed and tumor cells; thus exhibiting an antiproliferative effect on tumor growth. The 4-hydroxyestradiol:2- methoxyestradiol and 2-hydroxyestradiol:2-methoxyestradiol ratios therefore ought to be taken into account as possible indicators of carcinogenesis |
| Disciplines | Medicina |
| Paraules clau: | Diagnóstico, Ginecología y obstetricia, Oncología, Cáncer, Mama, Estradiol, Indicadores moleculares, Carcinogénesis |
| Keyword: | Medicine, Diagnosis, Gynecology and obstetrics, Oncology, Cancer, Breast, Estradiol, Molecular indicators, Carcinogenesis |
| Text complet: | Texto completo (Ver PDF) |
