The use of circulating cathodic antigen rapid test and serology for diagnosis of active Schistosoma mansoni infection in migrants in Italy, a non-endemic country: a cross sectional study
Document title: The use of circulating cathodic antigen rapid test and serology for diagnosis of active Schistosoma mansoni infection in migrants in Italy, a non-endemic country: a cross sectional study
Journal: Memorias do Instituto Oswaldo Cruz
Database: PERIÓDICA
System number: 000405555
ISSN: 0074-0276
Authors: 1
2
2
2
2
3
2
2
2
2
Institutions: 1Istituto Scientifico San Raffaele, Laboratorio di Microbiologia e Virologia, Milán, Lombardia. Italia
2Istituto Scientifico San Raffaele, Dipartimento di Malattie Infettive, Milán, Lombardia. Italia
3Health Pastoral Diocese of Bouar, Society of Priests of the Sacred Heart of Betharram, Bouar. República Centroafricana
Year:
Season: Jun
Volumen: 112
Number: 6
Pages: 452-455
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Experimental, aplicado
English abstract Diagnosis of schistosomiasis in migrants coming from endemic areas can be difficult, especially in asymptomatic subjects. Light-intensity disease, in fact, may be missed due to the low sensitivity of the stool microscopy and serologic testing cannot distinguish between a resolved infection and an active infection in patients who have been infected and treated in the past, because specific antibodies can persist despite cure. We describe a cross-sectional study conducted on 82 migrants tested for Schistosoma mansoni on single blood (anti-schistosome antibodies, total IgE) and urine [point-of-care (POC) circulating-cathodic-antigen (CCA) test] samples. A positive POC-CCA test (active infection) resulted in two untreated patients with a positive serology while all patients (n = 66) with a past infection showed a negative POC-CCA test. POC-CCA urine test in combination with serology may be helpful in rapidly differentiate active from past S. mansoni infection in migrants coming from endemic areas
Disciplines: Medicina
Keyword: Diagnóstico,
Salud pública,
Esquistosomiasis,
Pruebas diagnósticas,
Inmigrantes,
Serología,
Prueba rápida de antígeno catódico,
Schistosoma mansoni
Keyword: Medicine,
Diagnosis,
Public health,
Schistosomiasis,
Diagnostic tests,
Immigrants,
Serology,
Cathodic antigen rapid test,
Schistosoma mansoni
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