| Journal: | Memorias do Instituto Oswaldo Cruz |
| Database: | PERIÓDICA |
| System number: | 000405566 |
| ISSN: | 0074-0276 |
| Authors: | Oliveira, Gisele R. de1 Vieira, Valdimara C2 Avila, Emiliana C1 Finger-Jardim, Fabiana1 Caldeira, Thaís D.M1 Gatti, Fabiane A.A1 Goncalves, Carla V1 Oliveira, Sandro G3 Hora, Vanusa P. da1 Soares, Marcelo A2 Martinez, Ana M.B. de1 |
| Institutions: | 1Universidade Federal do Rio Grande, Escola de Medicina, Rio Grande, Rio Grande do Sul. Brasil 2Instituto Nacional de Cancer, Programa de Oncovirologia, Rio de Janeiro. Brasil 3Policlinica de Assistencia Medica, Rio Grande, Rio Grande do Sul. Brasil |
| Year: | 2017 |
| Season: | Jul |
| Volumen: | 112 |
| Number: | 7 |
| Pages: | 492-498 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Caso clínico |
| English abstract | Increasing evidence suggests that human papillomavirus (HPV) intratype variants (specific lineages and sublineages) are associated with pathogenesis and progression from HPV infection to persistence and the development of cervical cancer. OBJECTIVES This study aimed to verify the prevalence of HPV infection and distribution of HPV types and HPV16 variants in southern Brazil in women with normal cytology or intraepithelial lesions. METHODS HPV typing was determined by L1 gene sequencing. To identify HPV16 variants, the LCR and E6 regions were sequenced, and characteristic single nucleotide variants were identified. FINDINGS A total of 445 samples were studied, with 355 from cervical scrapes and 90 from cervical biopsies. HPV was detected in 24% and 91% of these samples, respectively. The most prevalent HPV types observed were 16 (cervical, 24%; biopsies, 57%) and 58 (cervical, 12%; biopsies, 12%). Seventy-five percent of the HPV16-positive samples were classified into lineages, with 88% defined as lineage A, 10% as lineage D, and 2% as lineage B. MAIN CONCLUSIONS This study identified a high frequency of European and North American HPV16 lineages, consistent with the genetic background of the human population in southern Brazil |
| Disciplines: | Medicina |
| Keyword: | Ginecología y obstetricia, Virus, Genética, Virus del papiloma humano, Linaje |
| Keyword: | Medicine, Gynecology and obstetrics, Virus, Genetics, Human papillomavirus, Lineage |
| Full text: | Texto completo (Ver HTML) |
