| Journal: | Genetics and molecular biology |
| Database: | PERIÓDICA |
| System number: | 000401321 |
| ISSN: | 1415-4757 |
| Authors: | Pare, Pamela1 Paixao-Cortes, Vanessa R2 Tovo Rodrigues, Luciana3 Vargas Pinilla, Pedro1 Bortolini, Maria Catira1 Viscardi, Lucas Henriques1 Salzano, Francisco Mauro1 Henkes, Luiz E4 |
| Institutions: | 1Universidade Federal do Rio Grande do Sul, Departamento de Genética, Porto Alegre, Rio Grande do Sul. Brasil 2Universidade Federal da Bahia, Instituto de Biologia, Salvador, Bahia. Brasil 3Universidade Federal de Santa Catarina, Laboratorio de Fisiologia da Reproducao Animal, Curitibanos, Santa Catarina. Brasil 4Universidade Federal de Pelotas, Programa de Pos-Graduacao em Epidemiologia, Pelotas, Rio Grande do Sul. Brasil |
| Year: | 2016 |
| Season: | Dic |
| Volumen: | 39 |
| Number: | 4 |
| Pages: | 646-657 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | Oxytocin receptor (OXTR) and arginine vasopressin receptors (AVPR1a, AVPR1b, and AVPR2) are paralogous genes that emerged through duplication events; along the evolutionary timeline, owing to speciation, numerous orthologues emerged as well. In order to elucidate the evolutionary forces that shaped these four genes in placental mammals and to reveal specific aspects of their protein structures, 35 species were selected. Specifically, we investigated their molecular evolutionary history and intrinsic protein disorder content, and identified the presence of short linear interaction motifs. OXTR seems to be under evolutionary constraint in placental mammals, whereas AVPR1a, AVPR1b, and AVPR2 exhibit higher evolutionary rates, suggesting that they have been under relaxed or experienced positive selection. In addition, we describe here, for the first time, that the OXTR, AVPR1a, AVPR1b, and AVPR2 mammalian orthologues preserve their disorder content, while this condition varies among the paralogues. Finally, our results reveal the presence of short linear interaction motifs, indicating possible functional adaptations related to physiological and/or behavioral taxa-specific traits |
| Disciplines: | Biología |
| Keyword: | Genética, Mamíferos, Bioquímica, Evolución molecular, Receptores químicos, Oxitocina, Vasopresina |
| Keyword: | Biology, Genetics, Mammals, Biochemistry, Molecular evolution, Chemical receptors, Oxytocin, Vasopressin |
| Full text: | Texto completo (Ver HTML) |
