| Journal: | Annals of hepatology |
| Database: | PERIÓDICA |
| System number: | 000406016 |
| ISSN: | 1665-2681 |
| Authors: | Altamirano Barrera, Alejandra1 Barranco Fragoso, Beatriz2 Méndez Sánchez, Nahum1 |
| Institutions: | 1Fundación Clínica Médica Sur, Unidad de Investigación de Hígado, Ciudad de México. México 2Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Centro Médico Nacional 20 de Noviembre, Ciudad de México. México |
| Year: | 2017 |
| Season: | Ene-Feb |
| Volumen: | 16 |
| Number: | 1 |
| Pages: | 48-56 |
| Country: | México |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico |
| English abstract | Liver fibrosis resulting from chronic liver injury are major causes of morbidity and mortality worldwide. Among causes of hepatic fibrosis, viral infection is most common (hepatitis B and C). In addition, obesity rates worldwide have accelerated the risk of liver injury due to nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). Also liver fibrosis is associated with the consumption of alcohol, or autoimmune hepatitis and chronic cholangiophaties. The response of hepatocytes to inflammation plays a decisive role in the physiopathology of hepatic fibrosis, which involves the recruitment of both pro- and anti-inflammatory cells such as monocytes and macrophages. As well as the production of other cytokines and chemokines, which increase the stimulus of hepatic stellate cells by activating proinflammatory cells. The aim of this review is to identify the therapeutic options available for the treatment of the liver fibrosis, enabling the prevention of progression when is detected in time |
| Disciplines: | Medicina |
| Keyword: | Gastroenterología, Terapéutica y rehabilitación, Fibrosis hepática, Cirrosis, Hepatitis, Enfermedades autoinmunes, Fisiopatología, Factores de riesgo, Medicamentos |
| Keyword: | Medicine, Gastroenterology, Therapeutics and rehabilitation, Hepatic fibrosis, Cirrhosis, Hepatitis, Autoimmune diseases, Physiopathology, Risk factors, Drugs |
| Full text: | Texto completo (Ver HTML) |
