| Revista: | Veterinaria México OA |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000439066 |
| ISSN: | 2007-5472 |
| Autores: | Maciel Rivera, Anaid1 Flores Villalva, Susana2 Jiménez Vázquez, Itzel1 Catalan Bárcenas, Omar1 Espitia Pinzón, Clara3 Moran, Julio4 Arriaga Pizano, Lourdes5 Benítez Guzmán, Alejandro1 Alfonseca Silva, Edgar1 Gutiérrez Pabello, José Ángel1 |
| Instituciones: | 1Universidad Nacional Autónoma de México, Facultad de Medicina Veterinaria y Zootecnia, Ciudad de México. México 2Instituto Nacional de Investigaciones Forestales, Agrícolas y Pecuarias, Centro Nacional de Investigación Disciplinaria, Querétaro. México 3Universidad Nacional Autónoma de México, Instituto de Investigaciones Biomédicas, Ciudad de México. México 4Universidad Nacional Autónoma de México, Instituto de Fisiología Celular, Ciudad de México. México 5Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Ciudad de México. México |
| Año: | 2019 |
| Periodo: | Ene-Mar |
| Volumen: | 6 |
| Número: | 1 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, analítico |
| Resumen en inglés | Species of the genus Mycobacterium are capable of inducing cell apoptosis. Infected cells with M. tuberculosis undergo apoptosis through a caspase-dependent pathway. We have previously shown that whole Mycobacterium bovis cells and derived crude protein extracts were able to trigger apoptosis through a caspase independent mechanism. However, the identity of the protein or protein fractions capable of inducing apoptosis has not been determined. In this study, bovine macrophages were incubated in the presence of Mycobacterium tuberculosis recombinant proteins and Mycobacterium bovis protein extracts to identify proteins capable of inducing apoptosis. A subgroup of proteins and protein extracts from strains of the Mycobacterium tuberculosis complex were shown to induce DNA fragmentation in bovine macrophages through a caspase independent pathway. Our findings suggest that bovine macrophages may elicit a different response to mycobacterium infection than that displayed by murine or human cells |
| Disciplinas: | Medicina veterinaria y zootecnia |
| Palabras clave: | Bovinos, Mycobacterium tuberculosis, Mycobacterium bovis, Tuberculosis, Zoonosis, Apoptosis, Macrófagos, Proteínas |
| Keyword: | Bovines, Mycobacterium tuberculosis, Mycobacterium bovis, Tuberculosis, Zoonoses, Macrophages, Proteins, Apoptosis |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
