| Revista: | The journal of venomous animals and toxins |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000298616 |
| ISSN: | 0104-7930 |
| Autores: | Theakston, R.D.G1 Kamiguti, A.S2 |
| Instituciones: | 1Liverpool School of Tropical Medicine, Alistair Reid Venom Research Unit, Liverpool, Lancashire. Reino Unido 2University of Liverpool, Royal Liverpool Hospital, Liverpool, Lancashire. Reino Unido |
| Año: | 1998 |
| Volumen: | 4 |
| Número: | 2 |
| Paginación: | 94-111 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | Treatment of systemic envenoming in snakebite victims has, in the past, depended almost entirely on the individual clinician's experience in assessing the severity of envenoming. The efficacy of treatment is obviously related to the neutralising potency of the antivenom used, the route by which it is administered and the dose. The use of techniques for evaluating the efficacy of antivenoms has proved to be very useful, as an adjunct to recognised clinical observations, for a more objective evaluation of antivenom efficacy and dosage. In patients bitten by many vipers, including the Brazilian pit vipers, the reversal of the venom-induced coagulopathy provides an ideal indicator as to the efficacy of an antivenom. Likewise, the development of enzyme immunoassay has permitted us to estimate levels of circulating specific venom and antivenom levels at any time after the bite in the patient's blood; the efficacy of an antivenom can thus be objectively assessed by measuring the neutralisation and clearance of venom antigen. In Brazil, it appears that clinicians treat patients with excessive amounts of highly efficient antivenoms, which results in an unacceptably high incidence of reactions. In Sri Lanka, the use of imported Indian antivenom is relatively ineffective in neutralising the procoagulant and other effects of the venoms of Sri Lankan snakes, demonstrating the real problem of venom variability within individual species. In West Africa, the improved restoration of blood coagulability, the resolution of haemorrhagic disturbances a |
| Disciplinas: | Medicina |
| Palabras clave: | Terapéutica y rehabilitación, Toxicología, Mordeduras de serpiente, Hemostasis, Inmunoensayo enzimático |
| Keyword: | Medicine, Therapeutics and rehabilitation, Toxicology, Snake bites, Haemostasis, Enzyme immunoassays |
| Texto completo: | Texto completo (Ver HTML) |
