The scorpion envenoming syndrome: a different perspective. The physiological basis of the role of insulin in scorpion envenoming



Título del documento: The scorpion envenoming syndrome: a different perspective. The physiological basis of the role of insulin in scorpion envenoming
Revista: The journal of venomous animals and toxins
Base de datos: PERIÓDICA
Número de sistema: 000298689
ISSN: 0104-7930
Autores: 1
Instituciones: 1Seth G.S. Medical College, Department of Physiology, Parel, Mumbai. India
Año:
Volumen: 6
Número: 1
Paginación: 4-51
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Analítico, descriptivo
Resumen en inglés Death caused by scorpion envenoming (Buthidae family) is a common event in tropical and subtropical countries. Severe scorpion envenoming causes an autonomic storm resulting in a massive release of catecholamines, angiotensin II, glucagon, cortisol, and changes in insulin secretion. As a consequence of these changes in the hormonal milieu, scorpion envenoming results in a syndrome of fuel energy deficits and an inability of the vital organs to utilize the existing metabolic substrates, which causes myocardial damage, cardiovascular disturbances, peripheral circulatory failure, pulmonary oedema, and many other clinical manifestations alone or in combination, producing multi-system-organ-failure (MSOF) and death. Insulin-glucose infusion or antivenom administration through the release of insulin seems to be the physiological basis for the control of the metabolic response when that has become a determinant to survival of scorpion sting victims
Disciplinas: Medicina
Palabras clave: Fisiología humana,
Toxicología,
Picaduras,
Alacranes,
Falla orgánica múltiple,
Catecolaminas,
Angiotensina II,
Glucagón,
Cortisol,
Insulina,
Daños,
Edema pulmonar,
Pulmones
Keyword: Medicine,
Human physiology,
Toxicology,
Scorpions,
Multiple organ failure,
Bites,
Catecholamines,
Angiotensin II,
Glucagon,
Cortisol,
Insulin,
Damage,
Pulmonary edema,
Lungs
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