| Revista: | The brazilian journal of infectious diseases |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000290757 |
| ISSN: | 1413-8670 |
| Autores: | Laval, Cristina Aparecida Borges1 Pimenta, Fabiana Cristina2 Andrade, Joao Guimaraes de2 Andrade, Soraya S3 Andrade, Ana Lucia S.S. de2 |
| Instituciones: | 1Secretaria de Saude, Goiania, Goias. Brasil 2Universidade Federal de Goias, Instituto de Patologia Tropical e Saude Publica, Goiania, Goias. Brasil 3Universidade Federal de Sao Paulo, Divisao de Doencas Infecciosas, Sao Paulo. Brasil |
| Año: | 2003 |
| Periodo: | Oct |
| Volumen: | 7 |
| Número: | 5 |
| Paginación: | 315-324 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Caso clínico, analítico |
| Resumen en inglés | Acute bacterial meningitis is an important cause of morbidity and mortality among children less than five years old. Haemophilus influenzae, Streptococcus pneumoniae and Neisseria meningitidis are the most important agents of bacterial meningitis in developing countries. The development of the conjugate vaccines in the beginning of the 90's, especially type b H. influenzae (Hib), and more recently the heptavalent pneumococcal and the serogroup C meningococcal vaccines, have contributed directly to changes in the epidemiological profile of these invasive diseases (direct effect) and of their carriage status (indirect effect). We review the impact of the Hib conjugate vaccine in Latin American countries, where this vaccine has been implemented, and the potential of pneumococcal and meningococcal conjugate vaccines for the reduction of meningitis worldwide. We also address constraints for the development and delivery of these vaccines and review new candidate state-of-the-art vaccines. The greatest challenge, undoubtedly, is to implement these vaccines worldwide, especially in the developing regions |
| Disciplinas: | Medicina |
| Palabras clave: | Neumología, Salud pública, Inmunología, Vacunas conjugadas, Vacunas conjugadas Hib, Vacuna antineumocócica conjugada, Vacuna antimeningocócica conjugada |
| Keyword: | Medicine, Pneumology, Public health, Conjugate vaccines, Hib conjugate vaccine, Pneumococcal conjugate vaccine, Meningococcal conjugate vaccine, Immunology |
| Texto completo: | Texto completo (Ver HTML) |
