| Revista: | The brazilian journal of infectious diseases |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000291047 |
| ISSN: | 1413-8670 |
| Autores: | Rossi, Flavia1 Andreazzi, Denise |
| Instituciones: | 1Universidade de Sao Paulo, Sao Paulo. Brasil |
| Año: | 2006 |
| Periodo: | Jun |
| Volumen: | 10 |
| Número: | 3 |
| Paginación: | 203-216 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Caso clínico |
| Resumen en inglés | The increasing antimicrobial resistance found in the many clinically important species of bacteria that commonly cause serious and life-threatening diseases presents a difficult challenge for clinicians, especially when an appropriate initial therapy must be chosen. New antibiotics are urgently needed to address the formidable issues associated with infections caused by vancomycin-resistant enterococci (VRE), methicillin-resistant Staphylococcus aureus (MRSA), penicillin-resistant Streptococcus pneumoniae and multidrug-resistant Gram-negative bacteria. The need for new antibiotics that effectively resist antimicrobial mechanisms of resistance has become paramount. Tigecycline is a new antimicrobial agent; it is the first in a new class of antibiotics, the glycylcyclines, with properties conferring the ability to overcome many common resistance mechanisms, thus allowing the use of tigecycline for many serious and life-threatening infections for which the use of other antibiotics is no longer appropriate. Tigecycline is a novel expanded spectrum antibiotic that appears poised to meet the latest bacterial challenges facing clinicians, including the serious and life-threatening infections caused by highly resistant bacteria. Tigecycline, moreover, appears to hold promise as a new, versatile antibiotic that can be chosen for empirical therapy, even as a single agent, for initial therapy of many clinically important infections |
| Disciplinas: | Medicina |
| Palabras clave: | Farmacología, Microbiología, Tigeciclina, Resistencia a antibióticos, Mecanismos antimicrobianos |
| Keyword: | Medicine, Microbiology, Pharmacology, Tigecycline, Antibiotic resistance, Antimicrobial mechanisms |
| Texto completo: | Texto completo (Ver HTML) |
