Does mycophenolate mofetil increase the risk of cytomegalovirus infection in solid organ transplant recipients?: A mini-review
Título del documento: Does mycophenolate mofetil increase the risk of cytomegalovirus infection in solid organ transplant recipients?: A mini-review
Revista: The brazilian journal of infectious diseases
Base de datos: PERIÓDICA
Número de sistema: 000291045
ISSN: 1413-8670
Autores: 1
2
3
Instituciones: 1Universidade de Sao Paulo, Departamento de Doencas Infecciosas e Parasitarias, Sao Paulo. Brasil
2Universidade de Sao Paulo, Divisao Transplante de Figado, Sao Paulo. Brasil
3Universidade de Sao Paulo, Departamento de Cirurgia, Sao Paulo. Brasil
Año:
Periodo: Abr
Volumen: 10
Número: 3
Paginación: 132-138
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Caso clínico
Resumen en inglés Mycophenolate mofetil (MMF) is currently used for prophylaxis of acute rejection in solid organ transplantation. There have been diverging reports regarding an association between MMF and the risk of cytomegalovirus (CMV) infection. We reviewed the main published studies in an attempt to clarify the association between the use of MMF and the risk, frequency and severity of CMV infections. In a search of the Medline database with the terms "mycophenolate" and "cytomegalovir", 42 articles were found to be relevant; among these, 29 articles were thoroughly analyzed. The first studies on MMF in renal transplantation already showed a tendency towards an association between this drug and the occurrence of CMV disease. Further studies were designed specifically to study this association; with the conclusion that an immunosuppressive regimen containing MMF increases the likelihood of CMV disease. Most studies were performed with kidney transplant recipients. We conclude that the use of MMF apparently increases the incidence of CMV disease in renal transplant patients; however, further studies are needed to confirm this association
Disciplinas: Química,
Medicina
Palabras clave: Bioquímica,
Cirugía,
Nefrología,
Micofenolato de mofetil,
Citomegalovirus,
Trasplantes
Keyword: Chemistry,
Medicine,
Biochemistry,
Nephrology,
Surgery,
Mycophenolate mofetil,
Cytomegalovirus,
Transplantation
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