| Revista: | The brazilian journal of infectious diseases |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000290951 |
| ISSN: | 1413-8670 |
| Autores: | Brito, Denise von Dolinger de1 Oliveira, Elias Jose Abdallah, Vania O. Steffen2 Darini, Ana Lucia da Costa3 Gontijo-Filho, Paulo Pinto |
| Instituciones: | 1Universidade Federal de Uberlandia, Laboratorio de Microbiologia, Uberlandia, Minas Gerais. Brasil 2Hospital Clínico, Uti Neonatal, Uberlandia, Minas Gerais. Brasil 3Universidade de Sao Paulo, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Ribeirao Preto, Sao Paulo. Brasil |
| Año: | 2005 |
| Periodo: | Ago |
| Volumen: | 9 |
| Número: | 4 |
| Paginación: | 301-309 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Caso clínico |
| Resumen en inglés | We studied an outbreak of two multi-drug resistant clones of Acinetobacter baumannii in the Neonatal Intensive Care Unit of the Uberlândia Federal University Hospital in Minas Gerais state, Brazil, and we analyzed the contribution of cross-transmission in the rise in infection rates. Eleven neonates who developed multi-drug resistant A. baumannii nosocomial infection were matched to 22 neonates who were admitted to the same unit and did not develop an infection during the outbreak period, in order to identify risk factors for infection. Three out of the 11 neonates died. Epidemiological investigation included molecular typing, using pulsed field gel electrophoresis. Prior to the outbreak, from December 2001 to March 2002, no case of infection by this microorganism was diagnosed. Environmental and healthcare worker hand cultures were negative. Nine isolates had similar pulsed field gel electrophoresis patterns and two had another clone. The first clone was brought into the unit by an infected patient who was transferred from another hospital without a history of antibiotic use. The second clone did have its origin clearly defined. Both infected groups led us to conclude that several factors contributed to infection with A. baumannii. These factors were: exposure to antibiotics and invasive devices, birth weight < 1500g, age < 7 days and duration of hospitalization > 7 days. Based on logistic regression, infected neonates were more exposed to carbapenem and mechanical ventilation than the control group. Cross transmission between infants contributed to the rise in the rates of multi-drug resistant A. baumannii infection |
| Disciplinas: | Medicina, Química |
| Palabras clave: | Microbiología, Pediatría, Bioquímica, Acinetobacter baumannii, Epidemiología molecular, Brote, Neonatos |
| Keyword: | Medicine, Chemistry, Microbiology, Pediatrics, Biochemistry, Acinetobacter baumannii, Molecular epidemiology, Outbreak, Neonates |
| Texto completo: | Texto completo (Ver HTML) |
