| Revista: | Salud mental |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000358457 |
| ISSN: | 0185-3325 |
| Autores: | Vega Rivera, Nelly Maritza1 Fernández Guasti, José Alonso2 Ramírez Rodríguez, Gerardo Bernabé3 Castro García, Mario1 Estrada Camarena, Erika1 |
| Instituciones: | 1Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Dirección de Neurociencias, México, Distrito Federal. México 2Instituto Politécnico Nacional, Centro de Investigación y de Estudios Avanzados, México, Distrito Federal. México 3Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Subdirección de Investigaciones Clínicas, México, Distrito Federal. México |
| Año: | 2012 |
| Periodo: | Nov-Dic |
| Volumen: | 35 |
| Número: | 6 |
| Paginación: | 527-533 |
| País: | México |
| Idioma: | Español |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico |
| Resumen en español | efectos de los estrógenos sobre la depresión y sobre su relación con la neurogénesis hipocámpica |
| Resumen en inglés | Estrogens produce a wide range of biological effects throughout the body, including the Central Nervous System (CNS). In the brain, besides acting as neuroprotective agents, estrogens play an important role in many neuronal processes and certain psychiatric disorders such as depression. The precise mechanism by which estrogens induce their positive effects on depressive disorders has not been elucidated; however, it is known that estrogens act on the CNS through the activation of specific receptors. These actions occur in genomic and non–genomics mechanisms through the modulation of synthesis and metabolism of neurotransmitters, neuropeptides, neurosteroids and influencing the morphological features of neurons and synaptic function. In addition, it is known that estrogens can act as modulators of processes related to neuroplasticity and neurogenesis. Adult hippocampal neurogenesis is a neuroplastic process that is affected by antidepressant drugs. These drugs increase the number of new neurons following a temporal course that correlates within the time in which antidepressants cause a behavioral improvement in rodents and in humans. Interestingly, whereas the behavioral antidepressant effects require 2–4 weeks to appear, after treatment initiation, estrogen reduce the depressive–like behavior and induce cell proliferation in terms of days. Thus, antidepressant drugs and the estrogens replacement during the adulthood could influence in a similar manner the new neuron formation. Furthermore, recent works have indicated that the combination of antidepressants plus estrogens could exert beneficial actions at lower doses of estrogens (physiological range). This evidence is important due to the combination of non–effective doses of antidepressants plus estrogens could decrease the side–effects of both compounds, and facilitate the behavioral action of antidepressant drugs shortening the latency to onset their action. The present review discusses.. |
| Disciplinas: | Medicina |
| Palabras clave: | Endocrinología, Neurología, Psiquiatría, Estrógenos, Depresión, Neurogénesis, Estrés, Antidepresivos |
| Keyword: | Medicine, Endocrinology, Neurology, Psychiatry, Estrogens, Depression, Neurogenesis, Stress, Antidepressants |
| Texto completo: | Texto completo (Ver HTML) |
