| Revista: | Revista médica de Chile |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000320104 |
| ISSN: | 0034-9887 |
| Autores: | Cañas, Miryan1 Morán, Yeinmy1 Rivero, María Belén1 Bohórquez, Adolfo2 Villegas, Venus2 Rendón, Yanet2 Ramírez, Eddy2 Valderrama, Elvis2 Briceño, Zuly1 Chiurillo, Miguel Angel1 |
| Instituciones: | 1Universidad Centroccidental "Lisandro Alvarado", Decanato de Ciencias de la Salud, Barquisimeto, Lara. Venezuela 2Universidad Centroccidental "Lisandro Alvarado", Hospital Antonio María Pineda, Barquisimeto, Lara. Venezuela |
| Año: | 2009 |
| Periodo: | Ene |
| Volumen: | 137 |
| Número: | 1 |
| Paginación: | 63-70 |
| País: | Chile |
| Idioma: | Español |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | Background: Genetic predisposition may playa role in the prevalence of gastric cancer (GC). Aim: To investígate the relationship between selected interleukin-1 (IL-1) loci polymorphisms and gastric cancer risk in the Central-Western región of Venezuela, where gastric cancer represents the first cause of cancer-related deaths. Material and methods: In a case-control study we compared the frequencies of IL-1B-511 and IL-1B+3954 biallelic polymorphism, and the pentallelic VNTR of IL-IRN in 84 gastric adenocarcinoma parafñn-embedded biopsies and 84 endoscopic biopsies from cancer-free controls. Results: No significant increase in genotypic frequencies in gastric cancer was observed for any ofthe IL-1B-511 allelic combinations. However, in a logistic regression analysis, a significant association emerged for the IL-1B+3954C carrier genotype (odds ratio (OR): 6.2; 95% confidence intervals (CI) 1.3-28.8). On the other hand, a significantly higherrisk was evidenced for the IL-IRN*2/*2genotype (OR: 7.0; 95% CI2.3-21.5). Onlypatients with a well/moderately-differentiated adenocarcinoma that were homozygotes for the E-IRN*2/*2 genotype, liad a higher risk than the complete gastric cancer group (OR: 8.1, 95% CI 2.5-26.8). Some genotype combinations among IL-1B-511, IL-1B+3954 and IL-IRN showed an increased risk for developing gastric cancer and well/moderate differentiated adenocarcinoma, that was dependent ofthe presence of IL-IRN*2/*2 genotype. Conclusions: IL-IRN*2/*2 genotype is associated with increased risk of gastric cancer in the Venezuelan population |
| Disciplinas: | Medicina |
| Palabras clave: | Gastroenterología, Oncología, Genética, Cáncer gástrico, Predisposición genética, Interleucinas, Polimorfismo genético |
| Keyword: | Medicine, Gastroenterology, Oncology, Gastric cancer, Genetic predisposition, Interleukins, Genetic polymorphism, Genetics |
| Texto completo: | Texto completo (Ver HTML) |
