| Revista: | Revista médica de Chile |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000448948 |
| ISSN: | 0034-9887 |
| Autores: | Cárdenas Oyarzo, Areli M1 Bocchieri Oyarce, Pamela A2 Méndez Laport, Cristian R3 Zolezzi, Juan M4 Ríos, Juvenal A5 |
| Instituciones: | 1Universidad Bernardo O'Higgins, Facultad de Ciencias Médicas, Santiago de Chile. Chile 2Universidad de Chile, Facultad de Medicina, Santiago de Chile. Chile 3Hospital Regional de Valdivia, Unidad de Radioterapia, Valdivia. Chile 4Universidad de Magallanes, Escuela de Medicina, Punta Arenas, Magallanes. Chile 5Universidad San Sebastián, Facultad de Medicina y Ciencia, Concepción. Chile |
| Año: | 2022 |
| Periodo: | Ene |
| Volumen: | 150 |
| Número: | 1 |
| Paginación: | 93-99 |
| País: | Chile |
| Idioma: | Español |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | Professors James P. Allison and Tasuku Honjo were awarded with the 2018 Nobel Prize in Medicine for their contributions in cancer immunotherapy. The latter is a breakthrough in cancer therapy, aimed to overcome tumor-induced immunosuppression, leading to the reactivation of the immune system against cancer cells. Under physiological conditions, the CTLA-4 and PD-1 proteins expressed on T-cells and discovered by the awarded scientists, lead to immune tolerance. Cancer cells exploit these control points to enhance the inhibition of T-cells. The expression of PD ligands (PD-L1) in tumor cells and CTLA-4 ligands in antigen presenting cells, which bind the PD-1 receptor and CTLA-4 respectively, block anti-tumor immunity. This situation led to a biotechnological race focused on the development of effective antibodies able to “turn-on” the immune system cheated by the tumor. Anti-CTLA-4 and anti-PD-1 antibodies improve life-expectancy in cancer patients. In this review, we perform an historical overview of Professors Allison and Honjo contribution, as well as the immunological basis of this new and powerful therapeutic strategy, highlighting the clinical benefits of such intervention |
| Disciplinas: | Medicina |
| Palabras clave: | Oncología, Inmunología, Cáncer, Inmunoterapia, Antígeno CTL-4, Inhibidores de control inmunológico, Muerte celular programada |
| Keyword: | Oncology, Immunology, Cancer, Immunotherapy, CTLA-4 antigen, Immune checkpoint inhibitors, Programmed cell death |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
