Prognostic Significance of the MAD1L1 1673 G:A Polymorphism in Ovarian Adenocarcinomas



Título del documento: Prognostic Significance of the MAD1L1 1673 G:A Polymorphism in Ovarian Adenocarcinomas
Revista: Revista de investigación clínica
Base de datos: PERIÓDICA
Número de sistema: 000453189
ISSN: 0034-8376
Autores: 1
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Instituciones: 1Universidad Nacional Autónoma de México, Instituto de Investigaciones Biomédicas, Ciudad de México. México
Año:
Periodo: Nov-Dic
Volumen: 72
Número: 6
Paginación: 372-379
País: México
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Experimental, aplicado
Resumen en inglés Background: Ovarian cancer is the most lethal gynecologic cancer. Although most patients respond adequately to the first-line therapy, up to 85% experience a recurrence of disease, which carries a poor prognosis. Mitotic arrest deficiency 1 is a protein that helps in the assembly of the mitotic spindle assembly checkpoint by preventing anaphase until all chromatids are properly aligned. A single-nucleotide polymorphism in the MAD1L1 gene is prevalent in patients with advanced epithelial ovarian cancer and alters the way in which it responds to chemotherapy. Objective: The objective of the study was to study the relationship between the rs1801368 polymorphism of MAD1L1 and prognosis of ovarian adenocarcinoma. Methods: A total of 118 patients in whom the MAD1L1 gene was sequenced were analyzed using descriptive and comparative statistics. Results: Patients carrying the wild-type genotype had a higher distribution of early-stage disease. Having a MAD1L1 polymorphic allele increased the risk of being non-sensitive to chemotherapy. The median disease-free survival for patients with the wild-type MAD1L1 was 46.93 months, compared to 10.4 months for patients with at least one polymorphic allele. Conclusions: The rs1801368 polymorphism of MAD1L1 gene worsens prognosis in patients with ovarian adenocarcinoma. Traditional therapy for ovarian cancer might not be optimal in patients carrying this polymorphism
Disciplinas: Medicina
Palabras clave: Oncología,
Ginecología y obstetricia,
Diagnóstico,
Adenocarcinoma,
Ovarios,
Polimorfismo genético,
Quimioterapia
Keyword: Gynecology and obstetrics,
Oncology,
Diagnosis,
Adenocarcinoma,
Ovaries,
Genetic polymorphism,
Chemotherapy
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