| Revista: | Revista de investigación clínica |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000454193 |
| ISSN: | 0034-8376 |
| Autores: | Torres, Nimbe1 Torre Villalvazo, Iván1 Tovar, Armando R1 |
| Instituciones: | 1Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Departamento de Fisiología de la Nutrición, Ciudad de México. México |
| Año: | 2019 |
| Periodo: | May-Jun |
| Volumen: | 71 |
| Número: | 3 |
| Paginación: | 157-167 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | Obesity is associated with an increase of several metabolic disorders leading to the development of diseases such as type 2 diabetes and cardiovascular disease. This is due in part to the ectopic accumulation of triglycerides in organs that are non-adipose tissues, leading to lipotoxicity. Particularly, in the liver, the accumulation of lipids, mainly of triglycerides, leads to the formation of fatty liver. The accumulation of lipids in skeletal muscle and pancreas associates with insulin resistance and a decrease in insulin secretion, respectively. In addition, it has been suggested that dysbiosis of the gut microbiota can contribute to the process of lipid accumulation in non-adipose tissues, especially in the liver. The aim of the present review is to highlight the mechanisms associated with the development of lipotoxicity, and how with the advances in nutrigenomics, it is now possible to understand the molecular mechanisms by which some nutrients can attenuate the ectopic accumulation of triglycerides in non-adipose tissues. Particularly, we emphasize research conducted on the molecular mechanisms of action of soy protein and some of its isoflavones, and how these can reduce lipotoxicity by preventing the accumulation of lipids in the liver, skeletal muscle, and pancreas, as well as their role on the gut microbiota to attenuate the development of fatty liver. Thus, nutrigenomics is opening new dietary strategies based on several functional foods that can be used to ameliorate the pathologies associated with lipotoxicity |
| Disciplinas: | Medicina |
| Palabras clave: | Metabolismo y nutrición, Lipotoxicidad, Hígado graso, Resistencia a la insulina, Tejido adiposo, Proteína de soya, Isoflavonas |
| Keyword: | Metabolism and nutrition, Lipotoxicity, Fatty liver, Insulin resistance, Adipose tissue, Soy protein, Isoflavones |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
