| Revista: | Revista de investigación clínica |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000454132 |
| ISSN: | 0034-8376 |
| Autores: | Martínez Magaña, José J1 Gonzalez Castro, Thelma B1 Genís Mendoza, Alma D2 Tovilla Zárate, Carlos A3 Juárez Rojop, Isela E1 Saucedo Uribe, Erasmo4 Rodríguez Mayoral, Oscar5 Lanzagorta, Nuria6 Escamilla, Michael7 Macías Kauffer, Luis8 Nicolini, Humberto2 |
| Instituciones: | 1Universidad Juárez Autónoma de Tabasco, División Aadémica de Ciencias de la Salud, Villahermosa, Tabasco. México 2Instituto Nacional de Medicina Genómica, Laboratorio de Genómica de Enfermedades Psiquiátricas y Neurodegenerativas, Ciudad de México. México 3Universidad Juárez Autónoma de Tabasco, División Académica Multidisciplinaria de Comalcalco, Comalcalco, Tabasco. México 4Universidad Autónoma de Nuevo León, Centro de Neurociencias, Monterrey, Nuevo León. México 5Instituto Nacional de Cancerología, Unidad de Cuidados Paliativos, Ciudad de México. México 6Grupo de Estudios Médicos y Familiares Carracci, Ciudad de México. México 7Texas Tech University, Health Sciences Center, El Paso, Texas. Estados Unidos de América 8Universidad Nacional Autónoma de México, Facultad de Química, Ciudad de México. México |
| Año: | 2019 |
| Periodo: | Sep-Oct |
| Volumen: | 71 |
| Número: | 5 |
| Paginación: | 321-329 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, crítico |
| Resumen en inglés | Concurrence of substance use disorders (SUDs) is high in individuals with psychiatric illnesses; more importantly, individuals with both disorders (dual diagnosis) have more severe symptoms. Psychiatric disorders have been proposed to share a genetic susceptibility with SUDs. To explore this shared genetic susceptibility, we analyzed whether any of the polygenic risk scores (PRSs) for psychiatric disorders could be associated to dual diagnosis in patients with schizophrenia (SCZ) or bipolar disorder (BD). Methods We included 192 individuals of Mexican ancestry: 72 with SCZ, 53 with BD, and 67 unrelated controls without psychiatric disorders. We derived calculations of PRS for autism spectrum disorders, attention-deficit/hyperactive disorder, BD, major depression, and SCZ using summary genome-wide association statistics previously published. Results We found that dual diagnosis had a shared genetic susceptibility with major depressive disorder (MDD) and SCZ; furthermore, in individuals with BD, dual diagnosis could be predicted by PRS for MDD. Conclusions Our results reinforce the notion that individuals with dual diagnosis have a higher genetic susceptibility to develop both disorders. However, analyses of larger sample sizes are required to further clarify how to predict risks through PRS within different populations |
| Disciplinas: | Medicina |
| Palabras clave: | Psiquiatría, Diagnóstico, Esquizofrenia, Trastorno bipolar, Diagnóstico dual, Registros poligénicos de riesgo |
| Keyword: | Psychiatry, Diagnosis, Dual diagnosis, Polygenic risk scores, Schizophrenia, Bipolar disorder |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
