| Revista: | Revista de investigación clínica |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000454128 |
| ISSN: | 0034-8376 |
| Autores: | Candelaria, Myrna1 Oñate Ocaña, Luis F1 Corona Herrera, Judith1 Barrera Carmona, Cristina2 Ponce Martínez, Mayra1 Gutiérrez Hernández, Olga1 Avilés Salas, Alejandro3 Cacho Díaz, Bernardo4 |
| Instituciones: | 1Instituto Nacional de Cancerología, División de Investigación Clínica, Ciudad de México. México 2Instituto Nacional de Cancerología, Departamento de Hematología, Ciudad de México. México 3Instituto Nacional de Cancerología, Departamento de Patología, Ciudad de México. México 4Instituto Nacional de Cancerología, Departamento de Neuro-Oncología, Ciudad de México. México |
| Año: | 2019 |
| Periodo: | Sep-Oct |
| Volumen: | 71 |
| Número: | 5 |
| Paginación: | 349-358 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | Background The outcome of patients with primary extranodal diffuse large B-cell lymphoma (PE-DLBCL) varies according to the primary site involved. Primary gastrointestinal, breast, bone, craniofacial, and testicular DLBCL are rare extranodal manifestations of DLBCL. Objective The objective of the study was to describe the clinical course of patients with PE-DLBCL disease in a referral cancer center. Results From 637 patients, 51 (8.77%) were considered as having PE-DLBCL (25 gastrointestinal, 12 craniofacial, 6 breast, 5 bone, and 3 with primary testicular DLBCL). Complete remission was higher in all PE-DLBCL sites (100% in testicular, 92.6% craniofacial, 83.3% breast, 80% bone, and 80% gastrointestinal) compared with 73.3% in nodal DLBCL. Although 2 cases with breast PE-DLBC relapsed, they achieved a complete response with chemotherapy. The overall survival at 5 years was 100%, 80%, 78%, 58%, 58%, and 62% for patients with primary breast, primary bone, gastrointestinal, primary craniofacial, primary testicular, and nodal DLBCL, respectively. Conclusions PE-DLBCLs constitute rare, primary sites of lymphoproliferative disorders in most cases, with localized disease and good prognosis. They require a combined chemoimmunotherapy with radiotherapy in most cases to improve local and systemic disease |
| Disciplinas: | Medicina |
| Palabras clave: | Oncología, Linfoma difuso de células B, Linfoma primario, Linfoma extranodal, Características clínicas |
| Keyword: | Oncology, Diffuse large B-cell lymphoma, Primary lymphoma, Extranodal lymphoma, Clinical characteristics |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
