| Revista: | Revista brasileira de psiquiatria |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000280052 |
| ISSN: | 1516-4446 |
| Autores: | Lima, Adriano Resende1 Bacaltchuk, Josue Ferraz, Marcos P.T |
| Instituciones: | 1Universidade Federal de Sao Paulo, Escola Paulista de Medicina, Sao Paulo. Brasil |
| Año: | 2001 |
| Periodo: | Jun |
| Volumen: | 23 |
| Número: | 2 |
| Paginación: | 110-116 |
| País: | Brasil |
| Idioma: | Portugués |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, caso clínico |
| Resumen en inglés | Neuroleptic-induced akathisia is a movement disorder related to the motor system characterized by complaints of inner restlessness, mental uneasiness, or dysphoria, all of which can be intense. Restlessness and non-dyskinetic movements are associated with these symptoms. This adverse effect to neuroleptics can lead to poor compliance with treatment, and thus, ultimately, to an increased risk of relapse. OBJECTIVES: To review the effectiveness and tolerability of beta-blockers, benzodiazepines and anticholinergics in the treatment of neuroleptic-induced akathisia, comparing each drug group with placebo and between each other, regardless of age or psychiatric diagnosis. METHODS: All controlled studies, obtained with certain search strategies, which fulfilled the inclusion criteria, were included in the review. Up to March 1999, seven electronic databases were assessed as well as the references of each clinical trial retrieved. RESULTS: There are 22 controlled clinical trials, 13 comparing beta-blockers, benzodiazepines and anticholinergics with placebo, and 9 comparing directly two or more active treatments. CONCLUSIONS: The three pharmacological interventions showed a better efficacy compared to placebo. Central action beta-blockers revealed a better efficacy when compared to peripheral action beta-blockers, benzodiazepines, and anticholinergics |
| Resumen en portugués | mostraram-se mais eficazes, quando comparados a betabloqueadores de ação periférica, benzodiazepínicos e anticolinérgicos |
| Disciplinas: | Medicina |
| Palabras clave: | Farmacología, Psiquiatría, Terapéutica y rehabilitación, Antagonistas, Beta adrenérgicos, Ansiolíticos, Anticolinérgicos, Acatisia, Antipsicóticos, Agitación psicomotora, Farmacoterapia, Efectos adversos |
| Keyword: | Medicine, Pharmacology, Psychiatry, Therapeutics and rehabilitation, Antagonists, Beta adrenergics, Anxiolytic agents, Anticholinergic agents, Psychomotor agitation, Antipsychotic agents, Drug therapy, Acathisia, Adverse effects |
| Texto completo: | Texto completo (Ver HTML) |
