| Revista: | Revista brasileira de hematologia e hemoterapia |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000305945 |
| ISSN: | 1516-8484 |
| Autores: | Souza, Wanessa C1 Torres, Felipe R Salvador, Ana R Tavora, Juvanete A2 Machado, Ricardo L.D3 Bonini-Domingos, Claudia R |
| Instituciones: | 1Universidade Estadual Paulista "Julio de Mesquita Filho", Departamento de Biologia, Sao Jose do Rio Preto, Sao Paulo. Brasil 2Hemocentro do Amapa, Macapa, Amapa. Brasil 3Faculdade de Medicina de Sao Jose do Rio Preto, Centro de Investigacao de Microorganismos, Sao Jose do Rio Preto, Sao Paulo. Brasil |
| Año: | 2003 |
| Volumen: | 25 |
| Número: | 4 |
| Paginación: | 263-265 |
| País: | Brasil |
| Idioma: | Portugués |
| Tipo de documento: | Correspondencia |
| Enfoque: | Descriptivo |
| Resumen en inglés | In malaria endemic regions of Africa, resistance to infection by Plasmodium has been observed in under 6-month-old children, when there are higher fetal hemoglobin (Hb F) levels. Research performed in the São José do Rio Preto region, central-east Brazil, reported increased levels of Hb F in blood donors. The purpose of this work was to evaluate the A2 hemoglobin (Hb A2) and Hb F concentrations in blood donors deriving from the Brazilian malaria endemic region. Forty-five blood donor samples from Macapá, from patients with varying genders, ages and ethnic origins, were collected by venous puncture after informed consent was obtained. The samples were analyzed by High Performance Liquid Chromatography (HPLC) - System Variant (Bio-Rad). The HPLC demonstrated sensitivity and rapidity in the identification and measurement of the hemoglobins and gave precise results. Moreover, it provided measurement of hemoglobin variants, even when they were present in small amounts, providing a diagnosis of hemoglobinopathies. Hb F levels above the normal were observed in 33.3% of the analyzed samples. The presence of increased Hb F can suggest resistance to infection by Plasmodium falciparum, as there have been reports that infected red blood cells interfere in the development of the parasite |
| Disciplinas: | Medicina |
| Palabras clave: | Hematología, Salud pública, Hemoglobina, Paludismo, Polimorfismo genético, Donadores de sangre, Resistencia a infecciones, Amazonas |
| Keyword: | Medicine, Hematology, Public health, Hemoglobin, Malaria, Genetic polymorphism, Blood donors, Infections resistance, Amazon |
| Texto completo: | Texto completo (Ver HTML) |
