| Revista: | RBM. Revista brasileira de medicina |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000323063 |
| ISSN: | 0034-7264 |
| Autores: | Goldberg, Henrique1 Nunes, Carlos Pereira2 Cardoso, Carlos Alfredo Franco2 Paoli, Flavia de2 Ribeiro, Marcia Goncalves1 Higashi, Rafael Geller, Mauro2 Oliveira, Lisa2 Marques, Cristiane3 |
| Instituciones: | 1Universidade Federal do Rio de Janeiro, Faculdade de Ciencias Medicas, Rio de Janeiro. Brasil 2Centro Universitario Serra dos Orgaos, Teresopolis, Rio de Janeiro. Brasil 3Hospital Municipal Miguel Couto, Rio de Janeiro. Brasil |
| Año: | 2009 |
| Periodo: | Jun |
| Volumen: | 66 |
| Número: | 6 |
| Paginación: | 169-173 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, caso clínico |
| Resumen en inglés | We evaluated the use of a combination of vitamins B1, B6, and B12 with dexamethasone in the treatment of the signs and symptoms of inflammatory neuropathy of the upper and lower limbs, in an open-label clinical trial. Patients were submitted to a 9-day treatment period with three doses of study medication at three day intervals, and a series of clinical and laboratory assessments, prior to the first dose of study medication and at each of the following three visits to the study center. Efficacy evaluations at each study visit included a 100mm VAS pain scale and global and satisfaction surveys completed by the patient and the investigating physician. Safety evaluations included a comparison of changes in laboratory evaluations at each visit and the incidence, severity, duration, and outcome of adverse events. A total of sixty-one patients were enrolled in the trial. A clinically significant improvement in all of the efficacy measures was observed from the pre-treatment to end-of-study evaluations. No clinically significant alterations in clinical assessments were observed during the treatment period. Based on the results of this clinical study, we conclude that the combination of dexamethasone with the B-vitamins is safe and effective in the treatment of the signs and symptoms of inflammatory neuropathy |
| Disciplinas: | Medicina |
| Palabras clave: | Farmacología, Neurología, Terapéutica y rehabilitación, Dexametasona, Neuropatías, Vitamina B |
| Keyword: | Medicine, Neurology, Pharmacology, Therapeutics and rehabilitation, Dexamethasone, Neuropathies, Vitamin B |
| Texto completo: | Texto completo (Ver HTML) |
